Introduction：Basic information about CAS 6093-71-6|Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate |
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| CAS Number | 6093-71-6 | Molecular Weight | 234.205 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 448.3±45.0 °C at 760 mmHg |
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| Molecular Formula | C12H10O5 | Melting Point | 170.0 to 174.0 °C |
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| MSDS | ChineseUSA | Flash Point | 178.7±22.2 °C |
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Names
| Name | ethyl 7-hydroxy-2-oxochromene-3-carboxylate |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM. Y29 also inhibits the HeLa cell growth with a GI50 of 2.7 µM[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| References | [1]. Minsuh Seo, et al. Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One. 2011;6(9):e24179. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 448.3±45.0 °C at 760 mmHg |
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| Melting Point | 170.0 to 174.0 °C |
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| Molecular Formula | C12H10O5 |
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| Molecular Weight | 234.205 |
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| Flash Point | 178.7±22.2 °C |
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| Exact Mass | 234.052826 |
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| PSA | 76.74000 |
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| LogP | 1.85 |
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| Appearance of Characters | white to beige |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.598 |
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| InChIKey | IETDBZQIWIJQJG-UHFFFAOYSA-N |
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| SMILES | CCOC(=O)c1cc2ccc(O)cc2oc1=O |
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| Storage condition | −20°C |
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| Water Solubility | DMSO: soluble5mg/mL, clear (warmed) |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 2932209090 |
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Customs
| HS Code | 2932209090 |
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| Summary | 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 3-carboethoxy-7-hydroxycoumarin |
| MFCD00017641 |
| 2H-1-Benzopyran-3-carboxylic acid, 7-hydroxy-2-oxo-, ethyl ester |
| 7-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid ethyl ester |
| 7-Hydroxycoumarin-3-carboxylic acid ethyl ester |
| ethyl 7-hydroxy-2-oxo-2H-[1]benzopyran-3-carboxylate |
| 3-CARBETHOXYUMBELIFERONE |
| Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate |
| Ethyl 7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylate |
| ethyl 7-hydroxycoumarin-3-carboxylate |
| 7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylic acid ethyl ester |
| 7-HYDROXY-2-OXO-CHROMENE-3-CARBOXYLIC ACID ETHYL ESTER |
| YZ9 |
| 1gcz |
| 3-carbethoxy-7-hydroxycoumarin |
