CAS 32004-67-4|Sulindac Sulfide
| Common Name | Sulindac Sulfide | ||
|---|---|---|---|
| CAS Number | 32004-67-4 | Molecular Weight | 340.411 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 526.3±50.0 °C at 760 mmHg |
| Molecular Formula | C20H17FO2S | Melting Point | 189-191°C |
| MSDS | ChineseUSA | Flash Point | 272.1±30.1 °C |
| Symbol | GHS07, GHS08 | Signal Word | Danger |
Names
| Name | Sulindac sulfide |
|---|---|
| Synonym | More Synonyms |
Sulindac Sulfide BiologicalActivity
| Description | (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM). (E/Z)-Sulindac sulfide selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer’s disease[1]. |
|---|---|
| Related Catalog | Research Areas >>Neurological Disease |
| Target | γ-secretase, Amyloid-β[1] |
| References | [1]. Richter L, et al. Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14597-602. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 526.3±50.0 °C at 760 mmHg |
| Melting Point | 189-191°C |
| Molecular Formula | C20H17FO2S |
| Molecular Weight | 340.411 |
| Flash Point | 272.1±30.1 °C |
| Exact Mass | 340.093323 |
| PSA | 62.60000 |
| LogP | 5.74 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.653 |
| InChIKey | LFWHFZJPXXOYNR-RQZCQDPDSA-N |
| SMILES | CSc1ccc(C=C2C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1 |
| Water Solubility | DMSO: >22 mg/mL |
Safety Information
| Symbol | GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H317-H334-H361 |
| Precautionary Statements | P261-P280-P342 + P311 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22;R42/43;R63 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles45
More Articles| Capping of aβ42 oligomers by small molecule inhibitors. Biochemistry 53(50) , 7893-903, (2014) Aβ42 peptides associate into soluble oligomers and protofibrils in the process of forming the amyloid fibrils associated with Alzheimer's disease. The oligomers have been reported to be more toxic to ... | |
| Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers. Drug Metab. Pharmacokinet. 30(1) , 70-4, (2015) Human flavin-containing monooxygenase 3 (FMO3) in the liver catalyzes a variety of oxygenations of nitrogen- and sulfur-containing medicines and xenobiotic substances. Because of growing interest in d... | |
| Sulindac sulfide--induced stimulation of eryptosis. Cell Physiol. Biochem. 30(4) , 1072-82, (2012) Sulindac sulfide, a non-steroidal anti-inflammatory drug (NSAID), stimulates apoptosis of tumor cells and is thus effective against malignancy. In analogy to apoptosis of nucleated cells, erythrocytes... |
Synonyms
| MFCD00869764 |
| {(1Z)-5-Fluoro-2-methyl-1-[4-(methylsulfanyl)benzylidene]-1H-inden-3-yl}acetic acid |
| (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid |
| 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1Z)- |
| EINECS 250-892-2 |
| SULINDAC SULFIDE |
| 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)inden-3-ylacetic acid ; [Sulindac Sulfide ] |
| 5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid |
