CAS 129121-73-9|Rat CGRP-(8-37)

Introduction：Basic information about CAS 129121-73-9|Rat CGRP-(8-37), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Rat CGRP-(8-37) BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Rat CGRP-(8-37)
CAS Number	129121-73-9	Molecular Weight	3127.51000
Density	/	Boiling Point	/
Molecular Formula	C₁₃₈H₂₂₄N₄₂O₄₁	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	CGRP 8-37 (rat)
Synonym	More Synonyms

Rat CGRP-(8-37) BiologicalActivity

Description	Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>CGRP ReceptorSignaling Pathways >>Neuronal Signaling >>CGRP ReceptorResearch Areas >>Cardiovascular DiseaseResearch Areas >>Neurological DiseasePeptides
Target	CGRP receptor[1]
In Vitro	CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor[1].
In Vivo	CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses[1]. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels[2].
Animal Admin	Rats: Adult male Sprague Dawley rats are given a spinal hemisection or a sham surgery at the T13 spinal segment. An externally accessible PE-10 intrathecal catheter that terminated at T13 is used for drug delivery. Animals are allowed to recover for 4 weeks at which time the hemisected animals displayed mechanical and thermal allodynia bilaterally, in both forelimbs and hindlimbs. CGRP-(8-37) is delivered just prior to a testing session in 1, 5, 10, or 50 nM doses in artificial cerebral spinal fluid in 10 mL volumes[1].
References	[1]. Bennett AD, et al. Alleviation of mechanical and thermal allodynia by CGRP(8-37) in a rodent model of chroniccentral pain. Pain. 2000 May;86(1-2):163-75. [2]. Yu LC, et al. The calcitonin gene-related peptide antagonist CGRP8-37 increases the latency to withdrawalresponses in rats. Brain Res. 1994 Aug 8;653(1-2):223-30.

Chemical & Physical Properties

Molecular Formula	C₁₃₈H₂₂₄N₄₂O₄₁
Molecular Weight	3127.51000
Exact Mass	3125.67000
PSA	1344.65000
LogP	0.05010
InChIKey	HZKKKBMPFPSSKZ-QZMRZBIOSA-N
SMILES	CC(C)CC(NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(NC(=O)C(N)C(C)C)C(C)O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(Cc1ccccc1)C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NCC(=O)NC(CO)C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)NC(Cc1ccccc1)C(N)=O)C(C)C)C(C)O)C(C)C)C(C)C)C(C)C
Storage condition	-20°C

Synonyms

h-val-thr-his-arg-leu-ala-gly-leu-leu-ser-arg-ser-gly-gly-val-val-lys-asp-asn-phe-val-pro-thr-asn-val-gly-ser-glu-ala-phe-nh2

val-thr-his-arg-leu-ala-gly-leu-leu-ser-arg-ser-gly-gly-val-val-lys-asp-asn-phe-val-pro-thr-asn-val-gly-ser-glu-ala-phe-nh2

vthrlagllsrsggvvkdnfvptnvgseaf-nh2

Rat CGRP-(8-37)

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