Introduction：Basic information about CAS 91431-42-4|Methotrexate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Methotrexate |
|---|
| CAS Number | 91431-42-4 | Molecular Weight | 338.74000 |
|---|
| Density | 1.309g/cm3 | Boiling Point | 424.9ºC at 760mmHg |
|---|
| Molecular Formula | C16H15ClO6 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 159.3ºC |
|---|
Names
| Name | (4-acetyloxy-6-chloro-2,3-dimethoxynaphthalen-1-yl) acetate |
|---|
| Synonym | More Synonyms |
|---|
Methotrexate BiologicalActivity
| Description | RS4317 is a topically effective 5-lipoxygenase (5-LO) inhibitor. |
|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>5-LipoxygenaseResearch Areas >>Inflammation/Immunology |
|---|
| Target | 5-lipoxygenase[1] |
|---|
| In Vitro | RS4317 (Lonapalene) may be useful in the treatment of psoriasis, and that leukotriene B4 is a relevant mediator of the pathology of this disease[1]. |
|---|
| References | [1]. Black AK, et al. Pharmacologic and clinical effects of lonapalene (RS 43179), a 5-lipoxygenase inhibitor, in psoriasis. J Invest Dermatol. 1990 Jul;95(1):50-4. |
|---|
Chemical & Physical Properties
| Density | 1.309g/cm3 |
|---|
| Boiling Point | 424.9ºC at 760mmHg |
|---|
| Molecular Formula | C16H15ClO6 |
|---|
| Molecular Weight | 338.74000 |
|---|
| Flash Point | 159.3ºC |
|---|
| Exact Mass | 338.05600 |
|---|
| PSA | 71.06000 |
|---|
| LogP | 3.36100 |
|---|
| Index of Refraction | 1.571 |
|---|
| InChIKey | IFWMVQUGSGWCRP-UHFFFAOYSA-N |
|---|
| SMILES | COc1c(OC)c(OC(C)=O)c2cc(Cl)ccc2c1OC(C)=O |
|---|
Synonyms
| 6-chloro-1,4-diacetoxy-2,3-dimethoxynaphthalene |
| LONAPALENE |
| Lonapaleno |
| Lonapalenum |
| 6-chloro-2,3-dimethoxy-1,4-naphthalenediol |
| 1,4-diacetoxy-6-chloro-2,3-dimethoxynaphthalene |
| 6-chloro-1,4-diacetyloxy-2,3-dimethoxynaphthalene |
| Methotrexate |
| RS4317 |
