Introduction：Basic information about CAS 605-62-9|4-Nitro-1-naphthol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4-Nitro-1-naphthol |
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| CAS Number | 605-62-9 | Molecular Weight | 189.167 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 398.8±25.0 °C at 760 mmHg |
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| Molecular Formula | C10H7NO3 | Melting Point | 165-168°C |
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| MSDS | / | Flash Point | 179.8±11.6 °C |
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Names
| Name | 4-Nitro-1-naphthol |
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| Synonym | More Synonyms |
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4-Nitro-1-naphthol BiologicalActivity
| Description | KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| Target | IC50: 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B)[1] |
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| In Vitro | KAT8-IN-1 (compound 19) losses anti-oxidant activity (EC50>1 mM)[1]. |
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| References | [1]. Wapenaar H, et al. The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. Eur J Med Chem. 2017 Aug 18;136:480-486. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 398.8±25.0 °C at 760 mmHg |
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| Melting Point | 165-168°C |
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| Molecular Formula | C10H7NO3 |
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| Molecular Weight | 189.167 |
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| Flash Point | 179.8±11.6 °C |
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| Exact Mass | 189.042587 |
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| PSA | 66.05000 |
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| LogP | 2.80 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.714 |
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| InChIKey | AUIRNGLMBHIITH-UHFFFAOYSA-N |
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| SMILES | O=[N+]([O-])c1ccc(O)c2ccccc12 |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R20/21/22 |
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| Safety Phrases | S26-S36/37/39 |
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| RIDADR | 2811 |
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| HS Code | 2908999090 |
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Customs
| HS Code | 2908999090 |
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| Summary | 2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| 4-nitronaphthalen-1-ol |
| 1-Naphthalenol, 4-nitro- |
| MFCD02179392 |
| 4-Nitro-1-naphthol |
