Introduction：Basic information about CAS 40680-87-3|Piprofurol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Piprofurol |
|---|
| CAS Number | 40680-87-3 | Molecular Weight | 455.54300 |
|---|
| Density | 1.214g/cm3 | Boiling Point | 640.7ºC at 760 mmHg |
|---|
| Molecular Formula | C26H33NO6 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 341.3ºC |
|---|
Names
| Name | 4-[3-[4,7-dimethoxy-6-(2-piperidin-1-ylethoxy)-1-benzofuran-5-yl]-3-hydroxypropyl]phenol |
|---|
| Synonym | More Synonyms |
|---|
Piprofurol BiologicalActivity
| Description | Piprofurol is a calcium channel inhibitor. Piprofurol inhibites in a concentration-dependent manner the calcium-induced contractions in isolated potassium depolarized preparations of rat aorta and relaxes the K+-induced contraction of the dog coronary artery and the rabbit basilar artery. Piprofurol exerts a negative inotropic effect on guinea-pig papillary muscle, with the EC50 of 5 μM[1]. |
|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Cardiovascular Disease |
|---|
| Target | 5 μM(guinea-pig papillary muscle)[1] |
|---|
| References | [1]. Pourrias B, et al. Calcium blocking properties of piprofurol. Arch Int Pharmacodyn Ther. 1985;274(2):223-239. |
|---|
Chemical & Physical Properties
| Density | 1.214g/cm3 |
|---|
| Boiling Point | 640.7ºC at 760 mmHg |
|---|
| Molecular Formula | C26H33NO6 |
|---|
| Molecular Weight | 455.54300 |
|---|
| Flash Point | 341.3ºC |
|---|
| Exact Mass | 455.23100 |
|---|
| PSA | 84.53000 |
|---|
| LogP | 4.62440 |
|---|
| Index of Refraction | 1.596 |
|---|
| InChIKey | LIAPJIQUUKLLDZ-UHFFFAOYSA-N |
|---|
| SMILES | COc1c(C(O)CCc2ccc(O)cc2)c(OCCN2CCCCC2)c(OC)c2occc12 |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DF6845120
- CHEMICAL NAME :
- 5-Benzofuranmethanol, 4,7-dimethoxy-alpha-(2-(4-hydroxyphenyl)ethyl)-6- (2-(1-piperidinyl)ethoxy)-
- CAS REGISTRY NUMBER :
- 40680-87-3
- BEILSTEIN REFERENCE NO. :
- 1276232
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C26-H33-N-O6
- MOLECULAR WEIGHT :
- 455.60
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 420 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1970- Volume(issue)/page/year: 8,125,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9900 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,85,1974
|
Synonyms
| EINECS 255-035-6 |
| Piprofurol |
| Piprofurol [INN] |
| Piprofurolum |
| Piprofurolum [INN-Latin] |
| 1-[4,7-dimethoxy-6-(2-piperidin-1-yl-ethoxy)-benzofuran-5-yl]-3-(4-hydroxy-phenyl)-propan-1-ol |
