CAS 113082-98-7|Enalkiren

Introduction：Basic information about CAS 113082-98-7|Enalkiren, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Enalkiren BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Enalkiren
CAS Number	113082-98-7	Molecular Weight	656.85600
Density	1.172g/cm3	Boiling Point	986.3ºC at 760mmHg
Molecular Formula	C₃₅H₅₆N₆O₆	Melting Point	/
MSDS	/	Flash Point	550.3ºC

Names

Name	3-amino-N-[(2S)-1-[[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-3-methylbutanamide
Synonym	More Synonyms

Enalkiren BiologicalActivity

Description	Enalkiren (A-64662) is a potent dipeptide renin inhibitor with an IC50 of 0.78 nM in a purified renal renin-angiotensinogen system (pH=6.0). Enalkiren suppresses renin activity, and also reduces systolic and diastolic blood pressure. Enalkiren can be used to research essential hypertension[1][2].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Renin
Target	IC50: 23 nM (hamster dipeptide renin), 14 nM (human dipeptide renin), 2.3 nM (cynomolgus monkey dipeptide renin)[2]
In Vitro	Enalkiren inhibits the endogenous renin-angiotensinogen reaction with an IC50 value of 23 nM, 14 nM and 2.3 nM in hamster, human and cynomolgus monkey plasma, respectively, at pH 7.4[2].
In Vivo	Enalkiren (0.01-10 mg/kg; i.v.; single dosage) reduces mean arterial blood pressure in cynomolgus monkey[2]. Animal Model: Cynomolgus monkey[2] Dosage: 0.01-10 mg/kg Administration: i.v.; single dosage Result: Reduced mean arterial blood pressure in a dose-related manner.

Chemical & Physical Properties

Density	1.172g/cm3
Boiling Point	986.3ºC at 760mmHg
Molecular Formula	C₃₅H₅₆N₆O₆
Molecular Weight	656.85600
Flash Point	550.3ºC
Exact Mass	656.42600
PSA	191.69000
LogP	4.39660
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.559
InChIKey	KQXVERRYBYGQJZ-WRPDIKACSA-N
SMILES	COc1ccc(CC(NC(=O)CC(C)(C)N)C(=O)NC(Cc2cnc[nH]2)C(=O)NC(CC2CCCCC2)C(O)C(O)CC(C)C)cc1

Synonyms

Enalquireno [INN-Spanish]

Enalkirene [INN-French]

ENALKIREN

Enalkirenum [INN-Latin]

Enalquireno

L-Histidinamide,N-(3-amino-3-methyl-1-oxobutyl)-O-methyl-L-tyrosyl-N-(1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)-,(1S-(1R*,2S*,3R*))

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