CAS 223652-90-2|Garenoxacin Mesylate

Introduction：Basic information about CAS 223652-90-2|Garenoxacin Mesylate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Garenoxacin Mesylate BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Garenoxacin Mesylate
CAS Number	223652-90-2	Molecular Weight	540.534
Density	/	Boiling Point	581.5ºC at 760 mmHg
Molecular Formula	C₂₄H₂₆F₂N₂O₈S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylic acid,methanesulfonic acid,hydrate
Synonym	More Synonyms

Garenoxacin Mesylate BiologicalActivity

Description	Garenoxacin mesylate hydrate is a novel oral des-fluoro(6) quinolone with potent antimicrobial activity, against common respiratory pathogens, including resistant strains.
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection
References	[1]. Waites KB, et al. In vitro susceptibilities to and bactericidal activities of garenoxacin (BMS-284756) and other antimicrobial agents against human mycoplasmas and ureaplasmas. Antimicrob Agents Chemother. 2003 Jan;47(1):161-5. [2]. Ince D, et al. Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone. Antimicrob Agents Chemother. 2002 Nov;46(11):3370-80. [3]. Zhao X, et al. Mutant prevention concentration of garenoxacin (BMS-284756) for ciprofloxacin-susceptible or -resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2003 Mar;47(3):1023-7.

Description

Garenoxacin mesylate hydrate is a novel oral des-fluoro(6) quinolone with potent antimicrobial activity, against common respiratory pathogens, including resistant strains.

Related Catalog

Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection

References

[1]. Waites KB, et al. In vitro susceptibilities to and bactericidal activities of garenoxacin (BMS-284756) and other antimicrobial agents against human mycoplasmas and ureaplasmas. Antimicrob Agents Chemother. 2003 Jan;47(1):161-5.

[2]. Ince D, et al. Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone. Antimicrob Agents Chemother. 2002 Nov;46(11):3370-80.

[3]. Zhao X, et al. Mutant prevention concentration of garenoxacin (BMS-284756) for ciprofloxacin-susceptible or -resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2003 Mar;47(3):1023-7.

Chemical & Physical Properties

Boiling Point	581.5ºC at 760 mmHg
Molecular Formula	C₂₄H₂₆F₂N₂O₈S
Molecular Weight	540.534
Exact Mass	540.137817
PSA	152.54000
LogP	5.31650
Vapour Pressure	2.29E-14mmHg at 25°C
InChIKey	IGTHEWGRXUAFKF-NVJADKKVSA-N
SMILES	CC1NCc2cc(-c3ccc4c(=O)c(C(=O)O)cn(C5CC5)c4c3OC(F)F)ccc21.CS(=O)(=O)O.O
Storage condition	2-8℃

Synonyms

Garenoxacin mesilate

Garenoxacin mesylate hydrate

3-Quinolinecarboxylic acid, 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-, methanesulfonate, hydrate (1:1:1)

BMS-284756-01

T-3811ME

Inforce

1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid methanesulfonate hydrate (1:1:1)

Garenoxacin Mesylate

Geninax

1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-5-isoindolyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid methanesulfonate monohydrate

Garenoxacin (Mesylate hydrate)

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