CAS 129655-21-6|Bizelesin

Introduction：Basic information about CAS 129655-21-6|Bizelesin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Bizelesin BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Bizelesin
CAS Number	129655-21-6	Molecular Weight	815.70300
Density	1.604g/cm3	Boiling Point	/
Molecular Formula	C₄₃H₃₆Cl₂N₈O₅	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	1,3-bis[2-[(8S)-8-(chloromethyl)-4-hydroxy-1-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-6-carbonyl]-1H-indol-5-yl]urea
Synonym	More Synonyms

Bizelesin BiologicalActivity

Description	Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>DNA Alkylator/Crosslinker
In Vitro	Bizelesin (0-5 μM, 4 h)可以通过靶向人类癌细胞 CEM 细胞中富含 AT的 DNA 域，造成 DNA 特异性损伤，进而造成癌细胞损伤，具有潜在的癌症治疗潜力[1]。 Bizelesin (0-500 nM)在 BSC-1 细胞中，当浓度为 10 nM 时导致 50% 的 DNA 合成抑制，相比之下，浓度为 160 nM 时才抑制 50% RNA 合成，而浓度高达至 200 nM 时也没有观察到蛋白质合成的抑制[2]。
References	[1]. J M Woynarowski, et al. AT-rich islands in genomic DNA as a novel target for AT-specific DNA-reactive antitumor drugs. J Biol Chem. 2001 Nov 2;276(44):40555-66. [2]. J M Woynarowski, et al. Effects of bizelesin (U-77,779), a bifunctional alkylating minor groove binder, on replication of genomic and simian virus 40 DNA in BSC-1 cells. Biochim Biophys Acta. 1997 Jul 17;1353(1):50-60.

Chemical & Physical Properties

Density	1.604g/cm3
Molecular Formula	C₄₃H₃₆Cl₂N₈O₅
Molecular Weight	815.70300
Exact Mass	814.21900
PSA	185.37000
LogP	9.52540
Index of Refraction	1.856
InChIKey	FONKWHRXTPJODV-UHFFFAOYSA-N
SMILES	Cc1c[nH]c2c(O)cc3c(c12)C(CCl)CN3C(=O)c1cc2cc(NC(=O)Nc3ccc4[nH]c(C(=O)N5CC(CCl)c6c5cc(O)c5[nH]cc(C)c65)cc4c3)ccc2[nH]1

Synonyms

Benzo(1,2-b:4,3-b')dipyrrol-4-ol,6,6'-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-,(S-(R*,R*))

U-77,779

BIZELESIN

Bizelesin (USAN/INN)

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