CAS 7456-24-8|Dimetotiazine
Introduction：Basic information about CAS 7456-24-8|Dimetotiazine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dimetotiazine | ||
|---|---|---|---|
| CAS Number | 7456-24-8 | Molecular Weight | 391.55100 |
| Density | 1.235g/cm3 | Boiling Point | 533.7ºC at 760 mmHg |
| Molecular Formula | C19H25N3O2S2 | Melting Point | / |
| MSDS | / | Flash Point | 276.6ºC |
Names
| Name | 10-[2-(dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide |
|---|---|
| Synonym | More Synonyms |
Dimetotiazine BiologicalActivity
| Description | Dimethothiazine (Dimetotiazine; Fonazine) is an orally active tricyclic anti-histamine, anti-5-HT agent with a high activity against decerebrate rigidity, a little sedative activity and little soporific action. Dimethothiazine can reduce or abolish the effects of both static and dynamic fusimotor activity on the muscle spindle in decerebrate cat. Dimethothiazine can be used to research hemicrania and spasticity[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT ReceptorSignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
| Target | Histamine, 5-HT[1] |
| In Vivo | Dimethothiazine (0.5-16 mg/kg; i.v.; single dosage) reduces decerebrate rigidity in cats[2]. Animal Model: Cats (decerebrate model; the carotid arteries were clamped and the mid-brain sectioned approximately between the colliculae)[2] Dosage: 0.5, 1, 2, 4, 8 and 16 mg/kg Administration: i.v.; single dosage Result: Reduced the discharge frequency of primary and secondary endings at 1-4 mg/kg. Reduced the sensitivity of the muscle spindle to stretch in preparations with intact ventral roots. Reduced the activity of the dynamic fusimotor fibres. |
| References | [1]. Nattero G, et al. Use of dimethothiazine in the prevention of hemicrania. Minerva Med. 1977 Mar 17;68(13):839-45. [2]. Maxwell DR, Rhodes KF. The effects of dimethothiazine on muscle spindle activity in the decerebrate cat. Br J Pharmacol. 1970 Jul;39(3):520-32. [3]. Griffiths MI, et al. The use of dimethothiazine in the treatment of childhood cerebral palsy. Dev Med Child Neurol. 1973 Feb;15(1):25-32. |
Chemical & Physical Properties
| Density | 1.235g/cm3 |
|---|---|
| Boiling Point | 533.7ºC at 760 mmHg |
| Molecular Formula | C19H25N3O2S2 |
| Molecular Weight | 391.55100 |
| Flash Point | 276.6ºC |
| Exact Mass | 391.13900 |
| PSA | 77.54000 |
| LogP | 4.63550 |
| Index of Refraction | 1.612 |
| InChIKey | VWNWVCJGUMZDIU-UHFFFAOYSA-N |
| SMILES | CC(CN1c2ccccc2Sc2ccc(S(=O)(=O)N(C)C)cc21)N(C)C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 740 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,70,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 190 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,70,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 475 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,70,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,70,1966 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 600 mg/kg
- SEX/DURATION :
- female 9-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,381,1970
Synonyms
| dimethothiazine |
| FONAZINE |
| Dimetiotazine |
| Dimethodin |
| 10-(2-dimethylamino-propyl)-10H-phenothiazine-2-sulfonic acid dimethylamide |
| Dimetotiazinum [INN-Latin] |
| N,N-Dimethyl-10-(2-dimethylaminopropyl)-phenothiazin-2-sulfonamide |
| Dimetotiazine |
| Dimetotiazine [INN:BAN] |
| Bayer 1483 |
| Dimetotiazina [INN-Spanish] |
| Dimetiotazin |
| Dimethothiazin |
