Introduction：Basic information about CAS 114798-36-6|Losartan Carboxaldehyde, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Losartan Carboxaldehyde |
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| CAS Number | 114798-36-6 | Molecular Weight | 420.895 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 666.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C22H21ClN6O | Melting Point | 84-86 °C |
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| MSDS | / | Flash Point | 357.0±34.3 °C |
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Names
| Name | 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carbaldehyde |
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| Synonym | More Synonyms |
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Losartan Carboxaldehyde BiologicalActivity
| Description | EXP3179 is an important intermediate aldehyde metabolite of Losartan. EXP3179 has no AT1-R–blocking activity, but potently inhibits the expression of endothelial cyclooxygenase (COX)-2. EXP3179 exerts potent anti-inflammatory actions[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COX |
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| References | [1]. Rossi GP. Losartan metabolite EXP3179: an AT1-receptor-independent treatment strategy for patients with the metabolic syndrome?. Hypertension. 2009;54(4):710-712. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 666.7±65.0 °C at 760 mmHg |
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| Melting Point | 84-86 °C |
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| Molecular Formula | C22H21ClN6O |
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| Molecular Weight | 420.895 |
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| Flash Point | 357.0±34.3 °C |
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| Exact Mass | 420.146545 |
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| PSA | 89.35000 |
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| LogP | 5.09 |
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| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
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| Index of Refraction | 1.681 |
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| InChIKey | FQZSMTSTFMNWQF-UHFFFAOYSA-N |
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| SMILES | CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 |
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Synonyms
| 1H-imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- |
| 2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-imidazole-5-carbaldehyde |
| 2-butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carbaldehyde |
| 2-Butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carbaldehyde |
| 2-n-Butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5-carboxaldehyde |
| 2-butyl-4-chloro-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde |
| [3H]-EXP 3179 |
| 1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- |
| EXP 3179 |
| 2-butyl-4-chloro-5-formyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methylimidazole |
| Losartan Carboxaldehyde |
| 2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carbaldehyde |
| 2-Butyl-4-chloro-1-[[2 inverted exclamation mark-(1H-tetrazol-5-yl)[1,1 inverted exclamation mark-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde |
| DUP 167 |
