CAS 72593-77-2|Methyl-PEG3-bromide

Introduction：Basic information about CAS 72593-77-2|Methyl-PEG3-bromide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameMethyl-PEG3-bromide
CAS Number72593-77-2Molecular Weight227.09600
Density1.288g/cm3Boiling Point245.798ºC at 760 mmHg
Molecular FormulaC7H15BrO3Melting Point/
MSDSChineseUSAFlash Point96.375ºC
Symbol
GHS07		Signal WordWarning

Names

NameDiethylene Glycol 2-Bromoethyl Methyl Ether
SynonymMore Synonyms

Methyl-PEG3-bromide BiologicalActivity

DescriptionMethyl-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related CatalogResearch Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target

PEGs

In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

Density1.288g/cm3
Boiling Point245.798ºC at 760 mmHg
Molecular FormulaC7H15BrO3
Molecular Weight227.09600
Flash Point96.375ºC
Exact Mass226.02000
PSA27.69000
LogP1.06090
Index of Refraction1.451
InChIKeyLCCCTXULXHJDLA-UHFFFAOYSA-N
SMILESCOCCOCCOCCBr

Safety Information

Symbol
GHS07
Signal WordWarning
Hazard StatementsH315-H319-H335
Precautionary StatementsP280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313
RIDADRNONH for all modes of transport

Synonyms

1-[2-(2-bromoethoxy)ethoxy]-2-methoxyethane
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