CAS 4602-84-0|farnesol
Introduction：Basic information about CAS 4602-84-0|farnesol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | farnesol | ||
|---|---|---|---|
| CAS Number | 4602-84-0 | Molecular Weight | 222.366 |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 283.4±0.0 °C at 760 mmHg |
| Molecular Formula | C15H26O | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 96.1±0.0 °C |
| Symbol | GHS07, GHS09 | Signal Word | Warning |
Names
| Name | farnesol |
|---|---|
| Synonym | More Synonyms |
farnesol BiologicalActivity
| Description | Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans, and has the activity in inhibiting bacteria. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>InfectionNatural Products >>Terpenoids and Glycosides |
| Target | Human Endogenous Metabolite |
| In Vitro | Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans. It is also shown that this molecule presents inhibitory effects against non-albicans Candida species, Paracoccidioides brasiliensis and bacteria. The minimum inhibitory concentrations (MICs) are determined in accordance with the M27-A3 protocol as described and Farnesol is tested at a concentration range of 0.29-150 μM. It is observed that Farnesol presents an inhibitory activity against C. neoformans and C. gattii (MIC range: 0.29-75.0 μM). Although Farnesol does not significantly alter phospholipase activity, a tendency to decrease this activity is observed[1]. |
| References | [1]. Cordeiro Rde A, et al. Farnesol inhibits in vitro growth of the Cryptococcus neoformans species complex with no significant changes in virulence-related exoenzymes. Vet Microbiol. 2012 Oct 12;159(3-4):375-80. |
Chemical & Physical Properties
| Density | 0.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 283.4±0.0 °C at 760 mmHg |
| Molecular Formula | C15H26O |
| Molecular Weight | 222.366 |
| Flash Point | 96.1±0.0 °C |
| Exact Mass | 222.198364 |
| PSA | 20.23000 |
| LogP | 5.31 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.485 |
| InChIKey | CRDAMVZIKSXKFV-FBXUGWQNSA-N |
| SMILES | CC(C)=CCCC(C)=CCCC(C)=CCO |
| Storage condition | −20°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7400 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 443 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic
MUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Insect - not otherwise specified Ovary
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 43,1285,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5190 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Insect - not otherwise specified Ovary
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 43,1285,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5190 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)
Safety Information
| Symbol | GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H317-H319-H411 |
| Precautionary Statements | P273-P280-P333 + P313-P337 + P313-P391-P501 |
| Personal Protective Equipment | Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US) |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R24/25 |
| Safety Phrases | S22-S24/25 |
| RIDADR | UN 3082 9 / PGIII |
| WGK Germany | 3 |
| RTECS | JR4979000 |
| HS Code | 2905290000 |
Customs
| HS Code | 2905290000 |
|---|---|
| Summary | 2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
Articles81
More Articles| Developmentally regulated sesquiterpene production confers resistance to Colletotrichum gloeosporioides in ripe pepper fruits. PLoS ONE 9(10) , e109453, (2014) Sesquiterpenoid capsidiol, exhibiting antifungal activity against pathogenic fungus, is accumulated in infected ripe pepper fruits. In this study, we found a negative relation between the capsidiol le... | |
| Farnesol induces apoptosis-like cell death in the pathogenic fungus Aspergillus flavus. Mycologia 106(5) , 881-8, (2014) Farnesol (FOH) is known to induce apoptosis in some fungi and mammalian cells. We treated Aspergillus flavus, one of the leading causes of human invasive aspergillosis and a key producer of the most p... | |
| Pluronics-Formulated Farnesol Promotes Efficient Killing and Demonstrates Novel Interactions with Streptococcus mutans Biofilms. PLoS ONE 10 , e0133886, (2015) Streptococcus mutans is the primary causative agent of dental caries, one of the most prevalent diseases in the United States. Previously published studies have shown that Pluronic-based tooth-binding... |
Synonyms
| (2-trans,6-trans)-farnesol |
| (E,E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol |
| Stirrup-TPW |
| Stirrup-HB |
| (2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trien-1-ol |
| trans,trans-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol |
| (2E,6E)-Farnesol |
| all-trans-farnesol |
| all-E-Farnesol |
| Farnesoi |
| EINECS 225-004-1 |
| MFCD00002918 |
| farnesyl bromide |
| 2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-, (E,E)- |
| (2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol |
| trans,trans-Farnesol |
| 2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-, (2E,6E)- |
| 3,7,10-trimethyl-2,6,10-dodecatrien-1-ol |
| ALL TRANS FARNESOL |
| FARNESOLP |
| trans-Farnesol |
| Farnesol,(E,E) |
| 3,7,11-Trimethyl-2,6,10-dodecatrienol |
| (E)-farnesol |
| farnesyl alcohol |
| (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol |
| 3,7,11-Trimethyl-2,6,10-Dodecatrien-1-ol |
| E,E-farnesol |
| Stirrup-CRW |
| Polyprenol |
| Stirrup-H |
| Farnesol |
| (E,E)-Farnesol |
| 3,7,11-Trimethyldodeca-2,6,10-trien-1-ol |
| 3,7,11-Trimethyldodeca-2-trans,6-trans,10-trien-1-ol |
| fci119a |
| Inhibitor A2 |
