CAS 29745-04-8|(±)-Norcantharidin

Introduction：Basic information about CAS 29745-04-8|(±)-Norcantharidin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (±)-Norcantharidin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles36
8. Synonyms

Common Name	(±)-Norcantharidin
CAS Number	29745-04-8	Molecular Weight	168.147
Density	1.5±0.1 g/cm3	Boiling Point	362.5±35.0 °C at 760 mmHg
Molecular Formula	C₈H₈O₄	Melting Point	114-116ºC
MSDS	ChineseUSA	Flash Point	167.0±26.0 °C

Names

Name	Norcantharidin
Synonym	More Synonyms

(±)-Norcantharidin BiologicalActivity

Description	(±)-Norcantharidin ((±)-NCTD) is a compound possessing anti-angiogenetic activity with potential use in anti-cancertherapy. (±)-Norcantharidin could prevent tumorigenesis by inhibiting cell proliferation, inducing apoptosis and the cell cycle arrest, and anti-angiogenic effects[1].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Inflammation/Immunology
In Vitro	(±)-Norcantharidin ((±)-NCTD) inhibits HMC cell proliferation, induces apoptosis, and affects the cell cycle[1].
References	[1]. Ye K, et al. Effect of norcantharidin on the proliferation, apoptosis, and cell cycle of human mesangialcells. Ren Fail. 2017 Nov;39(1):458-464.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	362.5±35.0 °C at 760 mmHg
Melting Point	114-116ºC
Molecular Formula	C₈H₈O₄
Molecular Weight	168.147
Flash Point	167.0±26.0 °C
Exact Mass	168.042252
PSA	52.60000
LogP	-0.85
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.550
InChIKey	JAABVEXCGCXWRR-FBXFSONDSA-N
SMILES	O=C1OC(=O)C2C3CCC(O3)C12

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RN8400000

CHEMICAL NAME :: 7-Oxabicyclo(2.2.1)heptane-2,3-dicarboxylic anhydride, exo-

CAS REGISTRY NUMBER :: 29745-04-8

BEILSTEIN REFERENCE NO. :: 0084287

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H8-O4

MOLECULAR WEIGHT :: 168.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 35,823,1987

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	RN8400000
HS Code	2932999099

Customs

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles36

Two triterpenoid glycosides from the roots of Camellia oleifera and their cytotoxic activity.

J. Asian Nat. Prod. Res. 17 , 800-7, (2015)

Two new triterpenoid saponins, oleiferoside N and oleiferoside O, were isolated from the EtOH extract from the roots of Camellia oleifera C. Abel. Their structures were elucidated as 16α-acetoxy-21β,2...

Cantharidin represses invasion of pancreatic cancer cells through accelerated degradation of MMP2 mRNA.

Sci. Rep. 5 , 11836, (2015)

Cantharidin is an active constituent of mylabris, a traditional Chinese medicine, and is a potent and selective inhibitor of protein phosphatase 2A (PP2A) that plays an important role in cell cycle co...

A novel cantharidin analogN-Benzylcantharidinamide reduces the expression of MMP-9 and invasive potentials of Hep3B via inhibiting cytosolic translocation of HuR

Biochem. Biophys. Res. Commun. 447(2) , 371-7, (2014)

Graphical abstract

Synonyms

(1R,2S,6R,7S)-4,10-Dioxatricyclo[5.2.1.0]decane-3,5-dione

norcantharadin

(3aR,4S,7R,7aS)-hexahydro-4,7-epoxy-2-benzofuran-1,3-dione

4,10-dioxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

exo-3,6-Epoxyhexahydrophthalic Anhydride

exo-7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Anhydride

MFCD00213361

Isocantharidin

demethyl cantharidin

4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-, (4R,7S)-

7-oxabicyclo[2,2,1]heptane-2,3-dicarboxylc acid anhydride

7-oxabicyclo[2,2,1]heptane-2,3-dicarboxylic acid anhydride

4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-, (3aR,4S,7R,7aS)-

(1R,7S)-4,10-Dioxatricyclo[5.2.1.0]decane-3,5-dione

endothallanhydride

Norcantharidin

exo,exo-4,10-dioxatricyclo[5.2.1.02.6]decane-3,5-dione

Exo-7-oxabicyclo(2.2.1)h

(4R,7S)-hexahydro-4,7-epoxy-2-benzofuran-1,3-dione

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