Introduction：Basic information about CAS 5231-60-7|vindorosine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | vindorosine |
|---|
| CAS Number | 5231-60-7 | Molecular Weight | 426.51 |
|---|
| Density | 1.3±0.1 g/cm3 | Boiling Point | 532.8±50.0 °C at 760 mmHg |
|---|
| Molecular Formula | C24H30N2O5 | Melting Point | 167° |
|---|
| MSDS | / | Flash Point | 276.0±30.1 °C |
|---|
Names
| Name | 1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid, 3a-ethyl-3a,4,5,5a,6,11,12,13a-octahydro-4,5-dihydroxy-6-methyl-, methyl ester, 4-acetate |
|---|
| Synonym | More Synonyms |
|---|
vindorosine BiologicalActivity
| Description | Vindorosine is an alkaloid from Catharanthus trichophyllus Roots. Vindorosine relaxes renal arteries[1][2]. |
|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
|---|
| References | [1]. Cordell GA, et al. Catharanthus alkaloids XXXII: isolation of alkaloids from Catharanthus trichophyllus roots and structure elucidation of cathaphylline. J Pharm Sci. 1976 Mar;65(3):366-9. [2]. Wu XL, et al. Antagonism of Ca2+ influx via L-type Ca2+ channels mediates the vasorelaxant effect of Catharanthus roseus-derived vindorosine in rat renal artery. Planta Med. 2014 Dec;80(18):1672-7. |
|---|
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|
| Boiling Point | 532.8±50.0 °C at 760 mmHg |
|---|
| Melting Point | 167° |
|---|
| Molecular Formula | C24H30N2O5 |
|---|
| Molecular Weight | 426.51 |
|---|
| Flash Point | 276.0±30.1 °C |
|---|
| Exact Mass | 426.215485 |
|---|
| PSA | 79.31000 |
|---|
| LogP | 2.30 |
|---|
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
|---|
| Index of Refraction | 1.635 |
|---|
| InChIKey | SASWULSUPROHRT-MCIGMTSASA-N |
|---|
| SMILES | CCC12C=CCN3CCC4(c5ccccc5N(C)C4C(O)(C(=O)OC)C1OC(C)=O)C32 |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NM2410000
- CHEMICAL NAME :
- 1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid, 3a-ethyl-3a,4,5,5a,6,11,12,13a-octahydro- 4,5-dihydroxy-6-methyl-, methyl ester, 4-acetate
- CAS REGISTRY NUMBER :
- 5231-60-7
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C24-H30-N2-O5
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04195
|
Safety Information
Synonyms
| methyl (2β,3β,4β,5α,12β,19α)-4-(acetyloxy)-3-hydroxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate |
| Demethoxyvindoline |
| Methyl (2β,3β,4β,5α,12β,19α)-4-acetoxy-3-hydroxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate |
| vindorosine |
| Vindorosin |
| Vindolidine |
| Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-3-hydroxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)- |
| Vindolidin |
