CAS 52-66-4|L-(+)-Penicillamine
Introduction：Basic information about CAS 52-66-4|L-(+)-Penicillamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | L-(+)-Penicillamine | ||
|---|---|---|---|
| CAS Number | 52-66-4 | Molecular Weight | 149.211 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 251.8±35.0 °C at 760 mmHg |
| Molecular Formula | C5H11NO2S | Melting Point | 208-212ºC |
| MSDS | ChineseUSA | Flash Point | 106.1±25.9 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | penicillamine |
|---|---|
| Synonym | More Synonyms |
L-(+)-Penicillamine BiologicalActivity
| Description | DL-Penicillamine [(±)-Penicillamine] is a copper chelating agent. DL-Penicillamine has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A). DL-Penicillamine can cause pyridoxine deficiency and then induce optic axial neuritis. DL-Penicillamine can also depress primary immune response[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vivo | DL-Penicillamine (25 mg/kg; i.p.; twice daily, for 5 days) has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A)[2]. Animal Model: Male Wistar rats, NIH strain (intoxicated by i.p. injection of 32 mg/kg thallium (I) acetate)[2] Dosage: 25 mg/kg Administration: i.p.; twice daily, for 5 days Result: Decreased slightly the thallium content in blood, organs and brain. Increased the probability survival when co-treated with Prussian blue (50 mg/kg; p.o.). |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 251.8±35.0 °C at 760 mmHg |
| Melting Point | 208-212ºC |
| Molecular Formula | C5H11NO2S |
| Molecular Weight | 149.211 |
| Flash Point | 106.1±25.9 °C |
| Exact Mass | 149.051056 |
| PSA | 102.12000 |
| LogP | 0.93 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.528 |
| InChIKey | VVNCNSJFMMFHPL-UHFFFAOYSA-N |
| SMILES | CC(C)(S)C(N)C(=O)O |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 365 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 209 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 358 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Phage inhibition capacity
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For publisher information, see AEMIDF. Volume(issue)/page/year: 12,234,1964 *** REVIEWS *** TOXICOLOGY REVIEW PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,465,1979
- TYPE OF TEST :
- Phage inhibition capacity
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For publisher information, see AEMIDF. Volume(issue)/page/year: 12,234,1964 *** REVIEWS *** TOXICOLOGY REVIEW PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,465,1979
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | S26;S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | YV9445000 |
| HS Code | 2930909090 |
Customs
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| 2-Amino-3-mercapto-3-methylbutanoic acid |
| 3-mercapto-L-valine |
| 3-Sulfanyl-L-valine |
| EINECS 200-147-2 |
| L-Penicillamine |
| DL-β,β-Dimethylcysteine |
| (R)-penicillamine |
| DL-β-Mercaptovaline |
| DL-Penicillamine |
| DL-Beta,Beta-Dimethylcysteine |
| DL-.β.-Mercaptovaline |
| (2R)-2-amino-3-mercapto-3-methyl-butyric acid |
| (2R)-2-amino-3-mercapto-3-methylbutanoic acid |
| MFCD00004856 |
| L-Valine, 3-mercapto- |
