CAS 24696-26-2|c16 ceramide

Introduction：Basic information about CAS 24696-26-2|c16 ceramide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Namec16 ceramide
CAS Number24696-26-2Molecular Weight537.90100
Density0.919g/cm3Boiling Point675.396ºC at 760 mmHg
Molecular FormulaC34H67NO3Melting Point94-95ºC
MSDS/Flash Point362.267ºC

Names

NameN-(1,3-dihydroxyoctadec-4-en-2-yl)hexadecanamide
SynonymMore Synonyms

c16 ceramide BiologicalActivity

DescriptionC16-Ceramide is a natural small molecule activating p53 through the direct and selective binding[1].
Related CatalogSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Apoptosis >>MDM-2/p53
Target

Human Endogenous Metabolite

In VitroC16-Ceramide interacts with p53 within its core domain. p53 forms complex with natural C16-Ceramide in the cell[1]. C16-Ceramide (2.5-50 μM; 0-48 h) strongly decreased HCT116 cell viability in a time- and concentration-dependent manner[2]. C16-Ceramide (12 μM; 48 h) induces apoptosis through Btf (Bcl-2-associated transcription factor) in HCT116 cells[2]. C16-ceramide (12 μM; 0-6 h) and Btf expression up-regulate p53 and BAX expression. C16-ceramide down-regulates Mdm2 expression via Btf[2]. Cell Viability Assay[2] Cell Line: HCT116 cells Concentration: 2.5, 5, 10, 12, 20, 50 µM Incubation Time: 0-48 h Result: Strongly decreased cell viability in a time- and concentration-dependent manner. Western Blot Analysis[2] Cell Line: HCT116 cells Concentration: 12 μM Incubation Time: 1, 3 and 6 h Result: Increased PARP cleavage, decreased pro-caspase 3. Decreased the levels of stratifin and stathmin, increased the expression of prohibitin and Btf. RNAi-mediated Btf depletion alsopartially inhibited BAX expression after the treatment. Significantly decreased luciferase activity and Mdm2 protein expression levels.

Chemical & Physical Properties

Density0.919g/cm3
Boiling Point675.396ºC at 760 mmHg
Melting Point94-95ºC
Molecular FormulaC34H67NO3
Molecular Weight537.90100
Flash Point362.267ºC
Exact Mass537.51200
PSA69.56000
LogP9.95390
Vapour Pressure0mmHg at 25°C
Index of Refraction1.48
InChIKeyYDNKGFDKKRUKPY-ZEWXNJAXSA-N
SMILESCCCCCCCCCCCCCC=CC(O)C(CO)NC(=O)CCCCCCCCCCCCCCC
Storage condition−20°C
Water SolubilitySoluble in DMF at 0.15mg/ml

Safety Information

Hazard CodesXi
Safety Phrases24/25
HS Code29225000

Synonyms

C16 CERAMIDE
N-(hexadecanoyl)-sphing-4-enine
N-Palmitoyl-D-sphingosine
N-PALMITOYL-D-SPHINGOSINE
C16-ceramide
N-Palmitoyl-D-erythro-sphingosine
Palmitoyl ceramide
N-Hexadecanoyl-D-sphingosine
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