CAS 226907-52-4|6-amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol

Introduction：Basic information about CAS 226907-52-4|6-amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name6-amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol
CAS Number226907-52-4Molecular Weight315.327
Density1.4±0.1 g/cm3Boiling Point626.4±65.0 °C at 760 mmHg
Molecular FormulaC15H17N5O3Melting Point/
MSDS/Flash Point332.6±34.3 °C

Names

Name6-amino-9-benzyl-2-(2-methoxyethoxy)-7H-purin-8-one
SynonymMore Synonyms

BiologicalActivity

DescriptionSM-360320 (CL-087) is a potent, oral actively TLR7 agonist. SM-360320 is a mmuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity[2].
Related CatalogSignaling Pathways >>Immunology/Inflammation >>Toll-like Receptor (TLR)Research Areas >>Inflammation/Immunology
References

[1]. Dharmapuri S, et al. An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models. Cancer Gene Ther. 2009;16(5):462-472.

[2]. Lee J, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103(6):1828-1833.

Chemical & Physical Properties

Density1.4±0.1 g/cm3
Boiling Point626.4±65.0 °C at 760 mmHg
Molecular FormulaC15H17N5O3
Molecular Weight315.327
Flash Point332.6±34.3 °C
Exact Mass315.133148
PSA108.31000
LogP0.21
Vapour Pressure0.0±1.9 mmHg at 25°C
Index of Refraction1.675
InChIKeyYYCDGEZXHXHLGW-UHFFFAOYSA-N
SMILESCOCCOc1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1

Safety Information

HS Code2933990090

Customs

HS Code2933990090
Summary2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

9-Benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine
Toll-Like Receptor 7 Ligand II
TLR7 Ligand II
6-Amino-9-benzyl-2-(2-methoxyethoxy)-7,9-dihydro-8H-purin-8-one
6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol
8H-Purin-8-one, 6-amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-
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