CAS 203805-87-2|HEPES-d18
Introduction：Basic information about CAS 203805-87-2|HEPES-d18, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | HEPES-d18 | ||
|---|---|---|---|
| CAS Number | 203805-87-2 | Molecular Weight | 256.415 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C8D18N2O4S | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | hepes (d18) |
|---|---|
| Synonym | More Synonyms |
HEPES-d18 BiologicalActivity
| Description | HEPES-d18 is the deuterium labeled HEPES[1]. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis[2][3][4]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828. [3]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 201066(Pt 4):482-492. [4]. Tol MJ, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 201814(3):437-449. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C8D18N2O4S |
| Molecular Weight | 256.415 |
| Exact Mass | 256.211700 |
| PSA | 89.46000 |
| LogP | -2.67 |
| Index of Refraction | 1.543 |
| InChIKey | JKMHFZQWWAIEOD-MMODJCGESA-N |
| SMILES | O=S(=O)(O)CCN1CCN(CCO)CC1 |
Synonyms
| Piperazine-2,2,3,3,5,5,6,6-d-1-ethane-α,α,β,β-d-sulfonic acid-d, 4-[2-(hydroxy-d)ethyl-1,1,2,2-d]- |
| 2-{4-[2-(H)Hydroxy(H)ethyl](H)-1-piperazinyl}(H)ethane(H)sulfonic acid |
| 2-{4-[2-(H)Hydroxy(H)ethyl](H)piperazin-1-yl}(H)ethane(H)sulfonic acid |
