CAS 480-11-5|oroxylin A

Introduction：Basic information about CAS 480-11-5|oroxylin A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. oroxylin A BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	oroxylin A
CAS Number	480-11-5	Molecular Weight	284.263
Density	1.4±0.1 g/cm3	Boiling Point	540.9±50.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₂O₅	Melting Point	195-197ºC
MSDS	/	Flash Point	207.4±23.6 °C

Names

Name	oroxylin A
Synonym	More Synonyms

oroxylin A BiologicalActivity

Description	Oroxylin A is a natural active flavonoid with strong anticancer effects.IC50 value:Target:In vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells [1]. Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells, inhibited HIF-1α expression and its stability [2]. Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation [3]. In vivo: Oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well [1].
Related Catalog	Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Metabolic Enzyme/Protease >>HIF/HIF Prolyl-HydroxylaseResearch Areas >>CancerNatural Products >>Flavonoids
References	[1]. Zhao K, et al. Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. J Hematol Oncol. 2015 Apr 23;8:41. http://www.ncbi.nlm.nih.gov/pubmed/25902914 [2]. Dai Q, et al. Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. Mol Carcinog. 2015 Aug 10. [3]. Wei L, et al. Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. Cell Death Dis. 2015 Apr 9

Description

Oroxylin A is a natural active flavonoid with strong anticancer effects.IC50 value:Target:In vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells [1]. Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells, inhibited HIF-1α expression and its stability [2]. Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation [3]. In vivo: Oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well [1].

Related Catalog

Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Metabolic Enzyme/Protease >>HIF/HIF Prolyl-HydroxylaseResearch Areas >>CancerNatural Products >>Flavonoids

References

[1]. Zhao K, et al. Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. J Hematol Oncol. 2015 Apr 23;8:41. http://www.ncbi.nlm.nih.gov/pubmed/25902914

[2]. Dai Q, et al. Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. Mol Carcinog. 2015 Aug 10.

[3]. Wei L, et al. Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. Cell Death Dis. 2015 Apr 9

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	540.9±50.0 °C at 760 mmHg
Melting Point	195-197ºC
Molecular Formula	C₁₆H₁₂O₅
Molecular Weight	284.263
Flash Point	207.4±23.6 °C
Exact Mass	284.068481
PSA	79.90000
LogP	2.37
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.669
InChIKey	LKOJGSWUMISDOF-UHFFFAOYSA-N
SMILES	COc1c(O)cc2oc(-c3ccccc3)cc(=O)c2c1O
Storage condition	2-8°C

Safety Information

Hazard Codes	Xn
Risk Phrases	22

Synonyms

Oroxylin

4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-phenyl-

baicalein 6-methyl ether

5,7-Dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one

5,7-Dihydroxy-6-methoxyflavone

6-Methoxybaicalein

oroxyllin-A

6-methoxy-5,7-dihydroxyflavone

5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one

oroxylin A

5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one 5,7-Dihydroxy-6-methoxyflavone

5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one

4H-1-Benzopyran-4-one,5,7-dihydroxy-6-methoxy-2-phenyl

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