CAS 9072-19-9|Fucoidan
| Common Name | Fucoidan | ||
|---|---|---|---|
| CAS Number | 9072-19-9 | Molecular Weight | 242.24700 |
| Density | / | Boiling Point | / |
| Molecular Formula | C7H14O7S | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | Fucoidan |
|---|---|
| Synonym | More Synonyms |
Fucoidan BiologicalActivity
| Description | Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseResearch Areas >>Metabolic Disease |
| In Vitro | Fucoidan is a biologically active polysaccharide found in great abundance in brown marine algae[1]. Fucoidan extracted from A. nodosum is a more potent inhibitor of α-glucosidase, with an IC50 ranging from 0.013 to 0.047 mg/mL, than the inhibition by Fucoidan extracted from F. vesiculosus (IC50=0.049 mg/mL). Fucoidan extracted from F. vesiculosus does not inhibit α-amylase activity, while Fucoidan from A. nodosum decreases α-amylase activity by 7-100% at 5 mg/mL depending upon the algae harvest period. Fucoidan from A. nodosum inhibits α-amylase with an IC50 of 0.12-4.64 mg/mL[1]. Fucoidan is a fucose-rich sulfated polysaccharide typically found in the cell wall of marine algae but also recently isolated from terrestrial sources. Fucoidan exhibits an attractive therapeutic potential against a wide array of metabolic diseases associated with oxidative stress[2]. |
| In Vivo | Fucoidan (single injection of 25 mg/kg/body) does not inhibit tumor cell proliferation, while three-time injections of 10 mg/kg/body weight significantly reduces tumor growth and metastasis[3]. Animal Model: Mice[3] Dosage: 10-400 mg/kg Administration: Intraperitoneal injection; followed by total-body irradiation Result: The mice injected with 100 mg/kg showed the best survival rate at 30 days post-irradiation. |
| References | [1]. Kyung-Tae Kim, et al. Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum.Phytochemistry. 2014 Feb;98:27-33. [2]. Zeinab El Rashed, et al. Antioxidant and Antisteatotic Activities of Fucoidan Fractions from Marine and Terrestrial Sources. Molecules. 2021 Jul 24;26(15):4467. [3]. Farzaneh Atashrazm, et al. Fucoidan and cancer: a multifunctional molecule with anti-tumor potential. Mar Drugs. 2015 Apr 14;13(4):2327-46. |
Chemical & Physical Properties
| Molecular Formula | C7H14O7S |
|---|---|
| Molecular Weight | 242.24700 |
| Exact Mass | 242.04600 |
| PSA | 121.67000 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | C |
| Risk Phrases | 34 |
| Safety Phrases | 26-27-36/37/39-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles40
More Articles| Antiproliferative activity of fucan nanogel. Mar. Drugs 10(9) , 2002-22, (2012) Sulfated fucans comprise families of polydisperse natural polysaccharides based on sulfated L-fucose. Our aim was to investigate whether fucan nanogel induces cell-specific responses. To that end, a n... | |
| Targeting P-selectin by gallium-68-labeled fucoidan positron emission tomography for noninvasive characterization of vulnerable plaques: correlation with in vivo 17.6T MRI. Arterioscler. Thromb. Vasc. Biol. 34(8) , 1661-7, (2014) Nuclear imaging of active plaques still remains challenging. Advanced atherosclerotic plaques have a strong expression of P-selectin by the endothelium overlying active atherosclerotic plaques, but no... | |
| Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects. Br. J. Nutr. 110(5) , 880-90, (2013) Laminaria japonica is traditionally eaten in Japan as a beneficial food for thrombosis. The alga contains two specific ingredients, a xanthophyll fucoxanthin (FX) and a polysaccharide, F-fucoidan (FD)... |
Synonyms
| MFCD00131109 |
| (2ξ,6S)-2,6-Anhydro-1-deoxy-6-methyl-5-O-sulfo-D-arabino-hexitol |
| D-galacto-Heptitol, 2,6-anhydro-1,7-dideoxy-, 3-(hydrogen sulfate), (6ξ)- |
| [(2S,3S,4S,5S,6R)-4,5-dihydroxy-2,6-dimethyl-tetrahydropyran-3-yl] hydrogen sulfate |
| (2S,3S,4S,5S,6R)-4,5-dihydroxy-2,6-dimethyltetrahydro-2H-pyran-3-yl hydrogen sulfate |
