CAS 41332-24-5|NP118809
Introduction：Basic information about CAS 41332-24-5|NP118809, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | NP118809 | ||
|---|---|---|---|
| CAS Number | 41332-24-5 | Molecular Weight | 460.609 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 618.9±55.0 °C at 760 mmHg |
| Molecular Formula | C32H32N2O | Melting Point | / |
| MSDS | / | Flash Point | 251.4±23.9 °C |
Names
| Name | 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one |
|---|---|
| Synonym | More Synonyms |
NP118809 BiologicalActivity
| Description | NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also less potently inhibits L-type calcium channel with an IC50 of 12.2 μM. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Cardiovascular Disease |
| Target | N-Type Ca2+ Channel:0.11 μM (IC50) L-type calcium channel:12.2 μM (IC50) |
| In Vitro | NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also inhibits L-type calcium channel with an IC50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC50 of 7.4 μM[1]. |
| In Vivo | NP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model[1]. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model[2]. |
| References | [1]. Zamponi GW, et al. Scaffold-based design and synthesis of potent N-type calcium channel blockers. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6467-72. [2]. Pajouhesh H, et al. Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1378-83. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 618.9±55.0 °C at 760 mmHg |
| Molecular Formula | C32H32N2O |
| Molecular Weight | 460.609 |
| Flash Point | 251.4±23.9 °C |
| Exact Mass | 460.251465 |
| PSA | 23.55000 |
| LogP | 6.51 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.622 |
| InChIKey | VCPMZDWBEWTGNW-UHFFFAOYSA-N |
| SMILES | O=C(CC(c1ccccc1)c1ccccc1)N1CCN(C(c2ccccc2)c2ccccc2)CC1 |
| Storage condition | 2-8℃ |
Synonyms
| 1-benzhydryl-4-(3,3-diphenyl-propionyl)-piperazine |
| 1-[4-(Diphenylmethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone |
| 1-Propanone, 1-[4-(diphenylmethyl)-1-piperazinyl]-3,3-diphenyl- |
| 1-(4-Benzhydryl-piperazin-1-yl)-3,3-diphenyl-propan-1-one |
| 1-(3,3-diphenylpropionyl)-4-benzhydryl piperazine |
| NP-118809 |
| NP118809 |
