Introduction：Basic information about CAS 174671-46-6|AN-2690, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | AN-2690 |
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| CAS Number | 174671-46-6 | Molecular Weight | 151.931 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 230.8±50.0 °C at 760 mmHg |
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| Molecular Formula | C7H6BFO2 | Melting Point | 120-122 °C |
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| MSDS | ChineseUSA | Flash Point | 93.4±30.1 °C |
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Names
| Name | tavaborole |
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| Synonym | More Synonyms |
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AN-2690 BiologicalActivity
| Description | Tavaborole (AN-2690) is an antifungal agent with activity against Trichophyton species, in a topical solution formulation for the potential treatment of onychomycosis. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>FungalResearch Areas >>Infection |
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| In Vitro | Tavaborole (AN-2690) shows an 8-fold increase in activity against C. neoformans, and an 8-fold increase in activity against A. fumigatus[1]. Tavaborole (AN-2690) obviously inhibit the cells expressing GlLeuRS-D444A, but has no effect on the cells expressing GlLeuRS and GlLeuRS-D444E[2]. |
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| References | [1]. Baker SJ, et al. Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis. J Med Chem. 2006 Jul 27;49(15):4447-50. [2]. Zhou XL, et al. Post-transfer editing by a eukaryotic leucyl-tRNA synthetase resistant to the broad-spectrum drug AN2690. Biochem J. 2010 Sep 1;430(2):325-33. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 230.8±50.0 °C at 760 mmHg |
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| Melting Point | 120-122 °C |
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| Molecular Formula | C7H6BFO2 |
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| Molecular Weight | 151.931 |
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| Flash Point | 93.4±30.1 °C |
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| Exact Mass | 152.044495 |
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| PSA | 29.46000 |
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| LogP | 0.04340 |
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| Vapour Pressure | 0.0±0.5 mmHg at 25°C |
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| Index of Refraction | 1.526 |
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| InChIKey | LFQDNHWZDQTITF-UHFFFAOYSA-N |
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| SMILES | OB1OCc2cc(F)ccc21 |
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Safety Information
| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| Tavaborole |
| 5-fluoro-1-hydroxy-3H-2,1-benzoxaborole |
| Kerydin |
| AN 2690 |
| onychomycosis |
| UNII-K124A4EUQ3 |
| 2,1-Benzoxaborole, 5-fluoro-1,3-dihydro-1-hydroxy- |
| 5-fluoro-1,3-dihydro-2,1-benzoxaborol-1-ol |
| 5-fluoro-3H-benzo[c][1,2]oxaborol-1-ol |
| 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole |
| 1,3-dihydro-5-fluoro-1-hydroxy-2,1-benzoxaborole |
| 5-fluorobenzo[c][1,2]oxaborol-1(3H)-ol |
| 5-Fluoro-2,1-benzoxaborol-1(3H)-ol |
| Tavaborole (USAN) |
| 2,1-Benzoxaborole,5-fluoro-1,3-dihydro-1-hydroxy |
| AN-2690 |
