Introduction：Basic information about CAS 1262770-73-9|KHS-101, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | KHS-101 |
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| CAS Number | 1262770-73-9 | Molecular Weight | 339.46 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C18H21N5S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | N4-isobutyl-N2-[(2-phenylthiazol-4-yl)methyl]pyrimidine-2,4-diami ne |
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| Synonym | More Synonyms |
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KHS-101 BiologicalActivity
| Description | KHS101 is a small molecule that accelerates neuronal differentiation. KHS101 can distributes to the brain and resulted in a significant increase in neuronal differentiation[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| In Vitro | KHS101 诱导贴壁培养大鼠 NPCs 神经元分化呈剂量依赖性 (EC50 ~ 1 μM)[1]。 KHS101 (5 μM) 抑制 NPCs 星形胶质细胞形成[1]。< br / >KHS101 (5 μM; 24-72 h) 对 NPCs 细胞周期进程和增殖有负面影响[1]。 KHS101 与 TACC3 蛋白特异性相互作用[1]。 KHS101 (0-15 μM; 24 h) 调控转录因子 ARNT2 的核定位[1]。 RT-PCR[1] Cell Line: Rat NPCs Concentration: 0.6, 1.7 and 5 μM Incubation Time: 24 h Result: Showed a dose-dependent induction of Cdkn1 mRNA expression. Cell Proliferation Assay[1] Cell Line: Rat NPCs Concentration: 5 μM Incubation Time: 24, 48 and 72 h Result: The vast majority of NPCs stop proliferating within 72 h, become mitotically inactive. |
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| In Vivo | KHS101 (6 mg/kg; s.c.; BID for 14 days) 在体内分布于大鼠脑内，显著促进神经元分化[1]。 Animal Model: Adult Fisher 344 rats (∼10 wk old)[1] Dosage: 6 mg/kg Administration: SC, BID for 14 days Result: Increased neuronal differentiation. Reduced proliferation of NPCs. |
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| References | [1]. Wurdak H, et al. A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16542-7. |
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Chemical & Physical Properties
| Molecular Formula | C18H21N5S |
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| Molecular Weight | 339.46 |
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| Exact Mass | 339.15200 |
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| PSA | 94.20000 |
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| LogP | 3.77500 |
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| InChIKey | DGRJOOOHPBSAHD-UHFFFAOYSA-N |
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| SMILES | CC(C)CNc1ccnc(NCc2csc(-c3ccccc3)n2)n1 |
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Synonyms
