CAS 936500-94-6|Elinogrel

Introduction：Basic information about CAS 936500-94-6|Elinogrel, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Elinogrel BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Elinogrel
CAS Number	936500-94-6	Molecular Weight	523.945
Density	1.7±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₂₀H₁₅ClFN₅O₅S₂	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	1-(5-chlorothiophen-2-yl)sulfonyl-3-[4-[6-fluoro-7-(methylamino)-2,4-dioxo-1H-quinazolin-3-yl]phenyl]urea
Synonym	More Synonyms

Elinogrel BiologicalActivity

Description	Elinogrel (PRT060128) is a potent, direct acting, competitive, and reversible platelet P2Y12 antagonist (IC50=20 nM). It is orally and intravenously available and has potent antiplatelet effects[1].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>P2Y Receptor
Target	IC50: 20 nM (P2Y12)[2]
References	[1]. Angiolillo DJ, et al. Pharmacokinetic and pharmacodynamic effects of elinogrel: results of the platelet function substudyfrom the intravenous and oral administration of elinogrel to evaluate tolerability and efficacy in nonurgent percutaneous coronary intervention patients (INNOVATE-PCI) trial. Circ Cardiovasc Interv. 2012 Jun;5(3):347-56. [2]. Jacobson KA, et al. Pharmacochemistry of the platelet purinergic receptors. Purinergic Signal. 2011 Sep;7(3):305-24.

Chemical & Physical Properties

Density	1.7±0.1 g/cm3
Molecular Formula	C₂₀H₁₅ClFN₅O₅S₂
Molecular Weight	523.945
Exact Mass	523.018738
PSA	182.53000
LogP	3.02
Index of Refraction	1.706
InChIKey	LGSDFTPAICUONK-UHFFFAOYSA-N
SMILES	CNc1cc2[nH]c(=O)n(-c3ccc(NC(=O)NS(=O)(=O)c4ccc(Cl)s4)cc3)c(=O)c2cc1F

Synonyms

2-Thiophenesulfonamide, 5-chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-

5-Chloro-N-({4-[6-fluoro-7-(methylamino)-2,4-dioxo-1,4-dihydro-3(2H)-quinazolinyl]phenyl}carbamoyl)-2-thiophenesulfonamide

Elinogrel

UNII-915Y8E749J

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