Introduction：Basic information about CAS 105365-76-2|RS 8359, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | RS 8359 |
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| CAS Number | 105365-76-2 | Molecular Weight | 252.271 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 483.6±45.0 °C at 760 mmHg |
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| Molecular Formula | C14H12N4O | Melting Point | / |
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| MSDS | / | Flash Point | 246.3±28.7 °C |
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Names
| Name | 4-[(7-Hydroxy-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)amino]be nzonitrile |
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| Synonym | More Synonyms |
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RS 8359 BiologicalActivity
| Description | RS 8359 is a selective and reversible MAO-A inhibitor, with antidepressant activity. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Monoamine OxidaseResearch Areas >>Neurological Disease |
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| In Vivo | RS 8359 shows relatively little effect upon blood pressure when administered together with tyramine. RS-8359 shows little affinity for the common central nervous system receptors and little anticholinergic effect[1]. |
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| References | [1]. Iwata N, et al. Pharmacology of the new reversible inhibitor of monoamine oxidase A, RS-8359. Int Clin Psychopharmacol. 1997 Sep;12 Suppl 5:S3-10. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 483.6±45.0 °C at 760 mmHg |
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| Molecular Formula | C14H12N4O |
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| Molecular Weight | 252.271 |
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| Flash Point | 246.3±28.7 °C |
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| Exact Mass | 252.101105 |
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| PSA | 81.83000 |
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| LogP | 1.12 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.682 |
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| InChIKey | YKTSVZRWKHWINV-UHFFFAOYSA-N |
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| SMILES | N#Cc1ccc(Nc2ncnc3c2CCC3O)cc1 |
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| Storage condition | 2-8℃ |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Benzonitrile, 4-[(6,7-dihydro-7-hydroxy-5H-cyclopenta[d]pyrimidin-4-yl)amino]- |
| 4-[(7-Hydroxy-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)amino]benzonitrile |
| UNII:79U9T1HIX9 |
| RS 8359 |
