Introduction：Basic information about CAS 5979-01-1|Xanthopterin Hydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Xanthopterin Hydrate |
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| CAS Number | 5979-01-1 | Molecular Weight | 197.15100 |
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| Density | / | Boiling Point | 458.7ºC at 760 mmHg |
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| Molecular Formula | C6H7N5O3 | Melting Point | >300 °C(lit.) |
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| MSDS | / | Flash Point | 231.2ºC |
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Names
| Name | xanthopterin monohydrate |
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| Synonym | More Synonyms |
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Xanthopterin Hydrate BiologicalActivity
| Description | Xanthopterin hydrate, an unconjugated pteridine compound, is the main component of the yellow granule in the Oriental hornet bear wings, produces a characteristic excitation/emission maximum at 386/456 nm[2]. Xanthopterin hydrate(XPT) causes renal growth and hypertrophy in rat[1].Xanthopterin hydrate inhibits RNA synthesis[4]. |
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| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisResearch Areas >>Inflammation/Immunology |
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| In Vitro | Xanthopterin (7.8-250 mM; 24 hours) show a significant reduction in mitochondrial activity with respect to controls (IC50=109 mM)[2]. Cell Viability Assay[2] Cell Line: MCF-7 cells Concentration: 7.8 mM-250 mM Incubation Time: 24 hours Result: Resulted in a reduction in mitochondrial activity. |
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| References | [1]. Xanthopterin (XPT), an unconjugated pteridine compound, affects cell growth and differentiation. When injected into rats, XPT has caused changes that have been interpreted as renal growth and hypertrophy. [2]. Lord JL, et al. Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells. Cancer Lett. 2005 May 10;222(1):119-24. [3]. Plotkin M, et al. Xanthopterin in the Oriental hornet (Vespa orientalis): light absorbance is increased with maturation of yellow pigment granules. Photochem Photobiol. 2009 Jul-Aug;85(4):955-61. [4]. Ziegler I, et al. Pterins and the regulation of lymphocyte activation on the mode of xanthopterin action. Hoppe Seylers Z Physiol Chem. 1984 Jun;365(6):667-73. |
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Chemical & Physical Properties
| Boiling Point | 458.7ºC at 760 mmHg |
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| Melting Point | >300 °C(lit.) |
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| Molecular Formula | C6H7N5O3 |
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| Molecular Weight | 197.15100 |
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| Flash Point | 231.2ºC |
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| Exact Mass | 197.05500 |
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| PSA | 127.27000 |
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| InChIKey | GXYCFNCAIXIUMR-UHFFFAOYSA-N |
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| SMILES | Nc1nc2ncc(=O)[nH]c2c(=O)[nH]1.O |
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Safety Information
| Safety Phrases | S22-S24/25 |
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| WGK Germany | 3 |
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Synonyms
| 2-AMINO-4,6-PTERIDINEDIOL |
| 2-aminopteridine-4,6-diol |
| XANTHOPTERIN(RG) |
| XANTHOPTERIN HYDRATE |
| 2-Amino-4,6-pteridindiol |
| MFCD00151242 |
| EINECS 204-325-0 |
