Introduction：Basic information about CAS 1762-34-1|Xeglyze, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Xeglyze |
|---|
| CAS Number | 1762-34-1 | Molecular Weight | 184.237 |
|---|
| Density | 1.1±0.1 g/cm3 | Boiling Point | 315.7±37.0 °C at 760 mmHg |
|---|
| Molecular Formula | C12H12N2 | Melting Point | 114-117 °C(lit.) |
|---|
| MSDS | ChineseUSA | Flash Point | 119.3±18.1 °C |
|---|
| Symbol |
GHS07 | Signal Word | Warning |
|---|
Names
| Name | 5-methyl-2-(5-methylpyridin-2-yl)pyridine |
|---|
| Synonym | More Synonyms |
|---|
Xeglyze BiologicalActivity
| Description | Abametapir is a metalloproteinase (MMP) inhibitor which is able to target metalloproteinases critical to egg hatching and louse development. Abametapir can inhibit hatching of both head and body louse[1][2]. |
|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Metabolic Enzyme/Protease >>MMP |
|---|
| In Vitro | Abametapir is capable of chelating heavy metal ions, including iron, copper, and zinc, and is therefore able to interact with a range of targets within the insect that require metal co-factors for function, including metalloproteinases[2]. |
|---|
| References | [1]. Vernon Morrison Bowles, et al. Effect of a New Head Lice Treatment, Abametapir Lotion, 0.74%, on Louse Eggs: A Randomized, Double-Blind Study. Glob Pediatr Health. 2019; 6: 2333794X19831295. [2]. Vernon M. Bowles, et al. Ovicidal Efficacy of Abametapir Against Eggs of Human Head and Body Lice (Anoplura: Pediculidae). J Med Entomol. 2017 Jan; 54(1): 167-172. |
|---|
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|
| Boiling Point | 315.7±37.0 °C at 760 mmHg |
|---|
| Melting Point | 114-117 °C(lit.) |
|---|
| Molecular Formula | C12H12N2 |
|---|
| Molecular Weight | 184.237 |
|---|
| Flash Point | 119.3±18.1 °C |
|---|
| Exact Mass | 184.100052 |
|---|
| PSA | 25.78000 |
|---|
| LogP | 2.20 |
|---|
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
|---|
| Index of Refraction | 1.566 |
|---|
| InChIKey | PTRATZCAGVBFIQ-UHFFFAOYSA-N |
|---|
| SMILES | Cc1ccc(-c2ccc(C)cn2)nc1 |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DW1766000
- CHEMICAL NAME :
- 2,2'-Bipyridine, 5,5'-dimethyl-
- CAS REGISTRY NUMBER :
- 1762-34-1
- BEILSTEIN REFERENCE NO. :
- 0123183
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C12-H12-N2
- MOLECULAR WEIGHT :
- 184.26
- WISWESSER LINE NOTATION :
- T6NJ E1 B- BT6NTJ E1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 225 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 23,815,1985
|
Safety Information
| Symbol |
GHS07 |
|---|
| Signal Word | Warning |
|---|
| Hazard Statements | H302-H315-H319-H335 |
|---|
| Precautionary Statements | P261-P305 + P351 + P338 |
|---|
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|
| Hazard Codes | Xi: Irritant; |
|---|
| Risk Phrases | R36/37/38 |
|---|
| Safety Phrases | S26-S36 |
|---|
| RIDADR | NONH for all modes of transport |
|---|
| WGK Germany | 3 |
|---|
| RTECS | DW1766000 |
|---|
| HS Code | 2933399090 |
|---|
Customs
| HS Code | 2933399090 |
|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|---|
Articles1
More Articles
| Synthesis, characterization and crystal structure determination of iron (III) hetero-ligand complexes containing 2, 2'-bipyridine, 5, 5'-dimethyl-2, 2'-bipyridine and chloride, [Fe(bipy)Cl4][bipy·H] and [Fe(dmbipy)2Cl2][FeCl4]. Amani V, et al. Polyhedron 26(15) , 4257-4262, (2007)
| |
Synonyms
| 5,5'-Dimethyl-2,2'-bipyridyl |
| 5,5′-dimethyl-2,2′-bipyridine |
| 5,5'-dimethyl-bpy |
| 5,5'-Dimethyl-2,2'-dipyridyl |
| 5,5'-dimethyl-2,2'-bipy |
| 6,6'-Di-3-picoline |
| MFCD01740554 |
| 5,5'-dimethyl-2,2'-bispyridine |
| Xeglyze |
| 2,2'-BIPYRIDINE,5,5'-DIMETHYL |
| 6,6'-Di-3-picolyl |
| 5,5'-Dimethyl-2,2'-bipyridine |
| 2,2'-Bipyridine, 5,5'-dimethyl- |
| abametapir |
