CAS 101-90-6|Resorcinol diglycidyl ether

Introduction：Basic information about CAS 101-90-6|Resorcinol diglycidyl ether, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
4. Safety Information
5. Customs
6. Articles8
7. Synonyms

Common Name	Resorcinol diglycidyl ether
CAS Number	101-90-6	Molecular Weight	222.237
Density	1.2±0.1 g/cm3	Boiling Point	364.3±12.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₄O₄	Melting Point	33-35°C
MSDS	ChineseUSA	Flash Point	156.6±26.4 °C
Symbol	GHS07, GHS08	Signal Word	Warning

Names

Name	2-[[3-(oxiran-2-ylmethoxy)phenoxy]methyl]oxirane
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	364.3±12.0 °C at 760 mmHg
Melting Point	33-35°C
Molecular Formula	C₁₂H₁₄O₄
Molecular Weight	222.237
Flash Point	156.6±26.4 °C
Exact Mass	222.089203
PSA	43.52000
LogP	1.15
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.557
InChIKey	WPYCRFCQABTEKC-UHFFFAOYSA-N
SMILES	c1cc(OCC2CO2)cc(OCC2CO2)c1
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	H2O: insoluble

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VH1050000

CHEMICAL NAME :: Resorcinol, diglycidyl-

CAS REGISTRY NUMBER :: 101-90-6

BEILSTEIN REFERENCE NO. :: 0203671

LAST UPDATED :: 199710

DATA ITEMS CITED :: 34

MOLECULAR FORMULA :: C12-H14-O4

MOLECULAR WEIGHT :: 222.26

WISWESSER LINE NOTATION :: T3OTJ B1OR CO1- BT3OTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2570 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from duodenum

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 178 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - peritonitis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 980 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 243 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - peritonitis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1240 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5320 mg/kg/14D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13 gm/kg/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10500 mg/kg/14D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 26 gm/kg/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6180 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25750 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6700 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 51500 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25750 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12875 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Heritable translocation test

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 50 ug/L

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 236,933,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,181,1985 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,181,1985 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83725 No. of Facilities: 193 (estimated) No. of Industries: 4 No. of Occupations: 8 No. of Employees: 2994 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83725 No. of Facilities: 28 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 1856 (estimated) No. of Female Employees: 222 (estimated)

Safety Information

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302 + H312-H315-H317-H319-H341-H351-H412
Precautionary Statements	P273-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	Xn:Harmful;
Risk Phrases	R21/22;R36/38;R40;R43;R52/53;R68
Safety Phrases	S23-S36/37-S61
RIDADR	2811
WGK Germany	2
RTECS	VH1050000
Packaging Group	II
Hazard Class	6.1
HS Code	2942000000

Customs

HS Code	2910900090
Summary	2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles8

Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines.

Environ. Mol. Mutagen. 52(7) , 547-61, (2011)

Included among the quantitative high throughput screens (qHTS) conducted in support of the US Tox21 program are those being evaluated for the detection of genotoxic compounds. One such screen is based...

Diglycidyl resorcinol ether.

IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 36 , 181-8, (1985)

Diglycidyl resorcinol ether.

Rep. Carcinog. 12 , 163-4, (2011)

Synonyms

2,2'-[1,3-phenylenebis(oxymethylene)]bis-oxirane

Diglycidylresorcinol ether

1,3-bis-oxiranylmethoxy-benzene

2,2'-[Benzene-1,3-diylbis(oxymethanediyl)]dioxirane

T3OTJ B1OR CO1- BT3OTJ

1,3-Bis-(2,3-epoxy-propoxy)-benzol

1,3-Bis(2,3-epoxypropoxy)benzene

Oxirane, 2,2'-[1,3-phenylenebis(oxymethylene)]bis-

diglycidyl ether of resorcinol

1,3-BENZENDIOL BIS(2-PROPENYL)ETHER BISEPOXIDE

Benzene,m-bis(2,3-epoxypropoxy)

MFCD00078378

Diglycidyl resorcinol ether

Araldite ERE 1359

meta-bis(glycidyloxy)benzene

EINECS 202-987-5

m-bis(glycidyloxy)benzene

2,2'-[1,3-Phenylenebis(oxymethylene)]dioxirane

DGRE

1,3-Bis(oxiran-2-ylmethoxy)benzene

diglicidyl resorcinol ether

1,3-Bis(glycidyloxy)benzene

RDGE

Resorcinyl diglycidyl ether

Resorcinol diglycidyl ether

1,3-DIGLYCIDYLOXYBENZENE

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