Introduction：Basic information about CAS 505-56-6|Docosanedioic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Docosanedioic acid |
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| CAS Number | 505-56-6 | Molecular Weight | 370.566 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 527.0±23.0 °C at 760 mmHg |
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| Molecular Formula | C22H42O4 | Melting Point | 72-80 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | 286.6±19.1 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | docosanedioic acid |
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| Synonym | More Synonyms |
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Docosanedioic acid BiologicalActivity
| Description | Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
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| Boiling Point | 527.0±23.0 °C at 760 mmHg |
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| Melting Point | 72-80 °C(lit.) |
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| Molecular Formula | C22H42O4 |
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| Molecular Weight | 370.566 |
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| Flash Point | 286.6±19.1 °C |
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| Exact Mass | 370.308319 |
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| PSA | 74.60000 |
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| LogP | 8.24 |
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| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
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| Index of Refraction | 1.474 |
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| InChIKey | DGXRZJSPDXZJFG-UHFFFAOYSA-N |
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| SMILES | O=C(O)CCCCCCCCCCCCCCCCCCCCC(=O)O |
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| Storage condition | 2-8°C |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36 |
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| RIDADR | UN 1824 |
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| WGK Germany | 3 |
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| HS Code | 2917190090 |
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Customs
| HS Code | 2917190090 |
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| Summary | 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| 1,22-Docosanedioic acid |
| 1,20-Eicosanedicarboxylic acid |
| Phellogenic acid |
| docosanedicarboxylic acid |
| MFCD00002807 |
| docosandioic acid |
| EINECS 204-010-8 |
| Phelogenic acid |
| Docosanedioic acid |
| 1,22-Docosanedoic acid |
| Docosandisaeure |
| Felogenic acid |
