Introduction：Basic information about CAS 5631-70-9|Trimethylapigenin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Trimethylapigenin |
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| CAS Number | 5631-70-9 | Molecular Weight | 312.31700 |
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| Density | 1.242g/cm3 | Boiling Point | 506.5ºC at 760mmHg |
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| Molecular Formula | C18H16O5 | Melting Point | 158-160ºC (dec.) |
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| MSDS | / | Flash Point | 225.5ºC |
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Names
| Name | 5,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one |
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| Synonym | More Synonyms |
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Trimethylapigenin BiologicalActivity
| Description | 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Epigenetics >>PARPSignaling Pathways >>Apoptosis >>CaspaseSignaling Pathways >>Cell Cycle/DNA Damage >>PARP |
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| Target | Caspase-3 PARP |
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| References | [1]. Kim H, et al. Induction of ER Stress-Mediated Apoptosis by the Major Component 5,7,4'-TrimethoxyflavoneIsolated from Kaempferia parviflora Tea Infusion. Nutr Cancer. 2018 Aug-Sep;70(6):984-996. |
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Chemical & Physical Properties
| Density | 1.242g/cm3 |
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| Boiling Point | 506.5ºC at 760mmHg |
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| Melting Point | 158-160ºC (dec.) |
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| Molecular Formula | C18H16O5 |
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| Molecular Weight | 312.31700 |
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| Flash Point | 225.5ºC |
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| Exact Mass | 312.10000 |
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| PSA | 57.90000 |
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| LogP | 3.48580 |
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| Index of Refraction | 1.585 |
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| InChIKey | ZXJJBDHPUHUUHD-UHFFFAOYSA-N |
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| SMILES | COc1ccc(-c2cc(=O)c3c(OC)cc(OC)cc3o2)cc1 |
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Safety Information
Customs
| HS Code | 2932999099 |
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| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 4',5,7-Trimethyl-apigenin |
| 4',5,7-Trimethoxyflavone |
| Apigenin trimethyl ether |
| 5,7,4'-Trimethylapigenin |
| apigenin 4',5,7-trimethyl ether |
| Trimethylapigenin |
