Introduction：Basic information about CAS 19877-89-5|vincanol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | vincanol |
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| CAS Number | 19877-89-5 | Molecular Weight | 296.40700 |
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| Density | 1.35 g/cm3 | Boiling Point | 484.4ºC at 760 mmHg |
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| Molecular Formula | C19H24N2O | Melting Point | / |
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| MSDS | / | Flash Point | 246.8ºC |
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Names
| Name | vincanol |
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| Synonym | More Synonyms |
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vincanol BiologicalActivity
| Description | Vincanol ((-)-Isoeburnamine) is a blocker of voltage-gated Na+ channels. Vincanol blocks Na+ currents with an IC50 value of 40 μM. Vincanol has neuroprotective effect[1]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>Neurological Disease |
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| References | [1]. Erdo SA, et al. Vincamine and vincanol are potent blockers of voltage-gated Na+ channels. Eur J Pharmacol. 1996 Oct 24;314(1-2):69-73. |
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Chemical & Physical Properties
| Density | 1.35 g/cm3 |
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| Boiling Point | 484.4ºC at 760 mmHg |
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| Molecular Formula | C19H24N2O |
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| Molecular Weight | 296.40700 |
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| Flash Point | 246.8ºC |
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| Exact Mass | 296.18900 |
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| PSA | 28.40000 |
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| LogP | 3.56320 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.719 |
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| InChIKey | HONLKDDLTAZVQV-UHOSZYNNSA-N |
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| SMILES | CCC12CCCN3CCc4c(n(c5ccccc45)C(O)C1)C32 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- JW4794332
- CHEMICAL NAME :
- Eburnamenin-14-ol, 14,15-dihydro-, (3-alpha,14-alpha,16-alpha)-
- CAS REGISTRY NUMBER :
- 19877-89-5
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C19-H24-N2-O
- MOLECULAR WEIGHT :
- 296.45
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 370 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2319362
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Synonyms
| 14,15-dihydro-eburnamenin-14-ol |
| 14-Doxylstearic acid |
| 14-DOXYL-octadecanoic acid |
| epi-eburnamine |
