Introduction：Basic information about CAS 1098-60-8|Triflupromazine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Triflupromazine hydrochloride |
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| CAS Number | 1098-60-8 | Molecular Weight | 388.878 |
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| Density | / | Boiling Point | 427.6ºC at 760 mmHg |
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| Molecular Formula | C18H20ClF3N2S | Melting Point | 174.0 to 179.0 °C |
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| MSDS | ChineseUSA | Flash Point | 212.4ºC |
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| Symbol |
GHS06 | Signal Word | Danger |
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Names
| Name | triflupromazine hydrochloride |
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| Synonym | More Synonyms |
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Triflupromazine hydrochloride BiologicalActivity
| Description | Triflupromazine hydrochloride is an antipsychotic medication, which are Dopamine D1/D2 receptor antagonists. |
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| Related Catalog | Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
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Chemical & Physical Properties
| Boiling Point | 427.6ºC at 760 mmHg |
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| Melting Point | 174.0 to 179.0 °C |
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| Molecular Formula | C18H20ClF3N2S |
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| Molecular Weight | 388.878 |
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| Flash Point | 212.4ºC |
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| Exact Mass | 388.098785 |
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| PSA | 31.78000 |
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| LogP | 6.12680 |
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| Vapour Pressure | 1.62E-07mmHg at 25°C |
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| InChIKey | FTNWXGFYRHWUKG-UHFFFAOYSA-N |
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| SMILES | CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21.Cl |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- SO8925000
- CHEMICAL NAME :
- Phenothiazine, 10-(3-(dimethylamino)propyl)-2-(trifluoromethyl)-, monohydrochloride
- CAS REGISTRY NUMBER :
- 1098-60-8
- LAST UPDATED :
- 199012
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C18-H19-F3-N2-S.Cl-H
- MOLECULAR WEIGHT :
- 388.91
- WISWESSER LINE NOTATION :
- T C666 BN ISJ B3N1&1 EXFFF
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 94 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 254 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 102 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 34 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 17 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory obstruction Blood - hemorrhage
MUTATION DATA - TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Mammal - species unspecified Kidney
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 8,617,1970
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Safety Information
| Symbol |
GHS06 |
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| Signal Word | Danger |
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| Hazard Statements | H301-H312 + H332 |
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| Precautionary Statements | Missing Phrase - N15.00950417-P261-P280 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
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| Hazard Codes | Xn: Harmful; |
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| Risk Phrases | R20/21/22 |
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| Safety Phrases | 36 |
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| RIDADR | UN 2811 6 |
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| WGK Germany | 3 |
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| RTECS | SO8925000 |
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| Packaging Group | III |
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Synonyms
| Triflupromazine HCl |
| Fluorofen |
| N,N-Dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]-1-propanamine hydrochloride (1:1) |
| Nivoman |
| Trifluopromazine hydrochloride |
| N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine,hydrochloride |
| flupromazine hydrochloride |
| N,N-Dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-amine hydrochloride (1:1) |
| 10-[3-(Dimethylamino)propyl]-2-(trifluoromethyl)phenothiazine hydrochloride |
| N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine hydrochloride |
| Phenothiazine, 10-(3-dimethylaminopropyl)-2-(trifluoromethyl)-, hydrochloride |
| Fluopromazinhydrochlorid |
| Vesprin hydrochloride |
| Neoprin |
| Flumazin |
| MFCD00058103 |
| Phenothiazine, 10-[3- (dimethylamino)propyl]-2-(trifluoromethyl)-, monohydrochloride |
| Triflupromazine monohydrochloride |
| EINECS 214-149-6 |
| Triflupromazine hydrochloride |
| 10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, hydrochloride (1:1) |
| triflupromazine |
