CAS 94596-28-8|Senkyunolide I

Introduction：Basic information about CAS 94596-28-8|Senkyunolide I, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Senkyunolide I BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Senkyunolide I
CAS Number	94596-28-8	Molecular Weight	224.253
Density	1.3±0.1 g/cm3	Boiling Point	444.8±45.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₆O₄	Melting Point	/
MSDS	/	Flash Point	175.1±22.2 °C

Names

Name	Senkyunolide I
Synonym	More Synonyms

Senkyunolide I BiologicalActivity

Description	Senkyunolide I, isolated from Ligusticum chuanxiong Hort, is an anti-migraine compound. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3[1][2].
Related Catalog	Signaling Pathways >>Apoptosis >>CaspaseResearch Areas >>Inflammation/Immunology
References	[1]. Wang YH, et al. Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. J Pharm Pharmacol. 2011 Feb;63(2):261-6. [2]. Hu Y, et al. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3. Brain Res. 2015 Apr 24;1605:39-48.

Description

Senkyunolide I, isolated from Ligusticum chuanxiong Hort, is an anti-migraine compound. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3[1][2].

Related Catalog

Signaling Pathways >>Apoptosis >>CaspaseResearch Areas >>Inflammation/Immunology

References

[1]. Wang YH, et al. Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. J Pharm Pharmacol. 2011 Feb;63(2):261-6.

[2]. Hu Y, et al. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3. Brain Res. 2015 Apr 24;1605:39-48.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	444.8±45.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₆O₄
Molecular Weight	224.253
Flash Point	175.1±22.2 °C
Exact Mass	224.104858
PSA	66.76000
LogP	1.04
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.571
InChIKey	DQNGMIQSXNGHOA-UHFFFAOYSA-N
SMILES	CCCC=C1OC(=O)C2=C1CCC(O)C2O
Storage condition	2-8℃

Safety Information

Hazard Codes	Xi

Synonyms

seneciphyllin

1(3H)-Isobenzofuranone, 3-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-, (3Z,6S,7S)-

SenkyunolideI

(3Z,6S,7S)-3-Butylidene-6,7-dihydroxy-4,5,6,7-tetrahydro-2-benzofuran-1(3H)-one

UNII:12PJ07292V

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