CAS 60934-46-5|(+/-)8-HETE

Introduction：Basic information about CAS 60934-46-5|(+/-)8-HETE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (+/-)8-HETE BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles26
6. Synonyms

Common Name	(+/-)8-HETE
CAS Number	60934-46-5	Molecular Weight	554.65000
Density	/	Boiling Point	615.3ºC at 760 mmHg
Molecular Formula	C₂₉H₄₉Na₂O₅P	Melting Point	/
MSDS	ChineseUSA	Flash Point	325.9ºC

Names

Name	sodium,[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] dihydrogen phosphate
Synonym	More Synonyms

(+/-)8-HETE BiologicalActivity

Description	α-Tocopherol phosphate (alpha-Tocopherol phosphate) disodium, a promising antioxidant, can protect against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium possesses therapeutic potential in the inhibition of apoptosis and increases the migratory capacity of endothelial progenitor cells under high-glucose/hypoxic conditions and promotes angiogenesis[1][2].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cardiovascular Disease
References	[1]. Saleh MM, et al. The photoprotective properties of α-tocopherol phosphate against long-wave UVA1 (385 nm) radiation in keratinocytes in vitro. Sci Rep. 2021 Nov 17;11(1):22400. [2]. Wu Z, et al. α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions. J Vasc Surg. 2018 Apr;67(4):1263-1273.e1.

Description

α-Tocopherol phosphate (alpha-Tocopherol phosphate) disodium, a promising antioxidant, can protect against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium possesses therapeutic potential in the inhibition of apoptosis and increases the migratory capacity of endothelial progenitor cells under high-glucose/hypoxic conditions and promotes angiogenesis[1][2].

Related Catalog

Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cardiovascular Disease

References

[1]. Saleh MM, et al. The photoprotective properties of α-tocopherol phosphate against long-wave UVA1 (385 nm) radiation in keratinocytes in vitro. Sci Rep. 2021 Nov 17;11(1):22400.

[2]. Wu Z, et al. α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions. J Vasc Surg. 2018 Apr;67(4):1263-1273.e1.

Chemical & Physical Properties

Boiling Point	615.3ºC at 760 mmHg
Molecular Formula	C₂₉H₄₉Na₂O₅P
Molecular Weight	554.65000
Flash Point	325.9ºC
Exact Mass	554.31100
PSA	91.46000
LogP	9.48250
InChIKey	LPWACMVJQSCQOF-RQGAJXLPSA-L
SMILES	Cc1c(C)c2c(c(C)c1OP(=O)([O-])[O-])CCC(C)(CCCC(C)CCCC(C)CCCC(C)C)O2.[Na+].[Na+]

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Articles26

Sodium dl-α-tocopheryl-6-O-phosphate inhibits PGE₂ production in keratinocytes induced by UVB, IL-1β and peroxidants.

Bioorg. Med. Chem. 19 , 6348-55, (2011)

The water-soluble vitamin E derivative, sodium dl-α-tocopheryl-6-O-phosphate (1), exhibits protective effects against skin damage. As reported herein, we investigated the actions of 1 on the formation...

Analysis of vitamin E metabolites in biological specimen.

Mol. Nutr. Food. Res. 54(5) , 588-98, (2010)

Vitamin E is known as the most important lipid antioxidant and is widely used to prevent age-associated diseases. Despite increasing knowledge about human vitamin E metabolism, little is known to just...

α-tocopherol and α-tocopheryl phosphate interact with the cannabinoid system in the rodent hippocampus.

Free Radic. Biol. Med. 51(9) , 1643-55, (2011)

α-Tocopherol (α-TOH), a dietary component of vitamin E, is well known for its antioxidant capacity. Nevertheless, recent studies have pointed out non-anti-radical properties including cellular and gen...

Synonyms

MFCD00079579

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