Introduction：Basic information about CAS 52617-37-5|Ponicidin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ponicidin |
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| CAS Number | 52617-37-5 | Molecular Weight | 362.417 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 580.9±50.0 °C at 760 mmHg |
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| Molecular Formula | C20H26O6 | Melting Point | / |
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| MSDS | / | Flash Point | 210.0±23.6 °C |
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Names
| Name | ponicidin |
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| Synonym | More Synonyms |
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Ponicidin BiologicalActivity
| Description | Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens, and exhibits immunoregulatory, anti-inflammatory, anti-viral and anti-cancer activity. Ponicidin (Rubescensine B) induces apoptosis of gastric carcinoma cell, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
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| Target | Apoptosis[1] |
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| References | [1]. Liu YF, et al. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. Int J Mol Sci. 2015 Jan 12;16(1):1576-89. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 580.9±50.0 °C at 760 mmHg |
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| Molecular Formula | C20H26O6 |
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| Molecular Weight | 362.417 |
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| Flash Point | 210.0±23.6 °C |
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| Exact Mass | 362.172943 |
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| PSA | 96.22000 |
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| LogP | 3.11 |
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| Vapour Pressure | 0.0±3.7 mmHg at 25°C |
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| Index of Refraction | 1.649 |
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| InChIKey | WHRDRHNMTIXZNY-ISUYKJBHSA-N |
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| SMILES | C=C1C(=O)C23C4OC5OC2(O)C(O)C2C(C)(C)CCC(O)C52C3CCC14 |
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| Storage condition | 2-8℃ |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NZ8176600
- CAS REGISTRY NUMBER :
- 52617-37-5
- LAST UPDATED :
- 199506
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C20-H26-O6
- MOLECULAR WEIGHT :
- 362.46
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 55800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85PEAG "Zhongliu Yanjiu" Cancer Review, Yu, R., et al., eds., Shanghai Science/Technology Publisher, Peop. Rep. China, 1994 Volume(issue)/page/year: -,187,1994
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Safety Information
Synonyms
| (1α,5β,6β,7β,8α,9β,10α,14S,20S)-1,6,7-Trihydroxy-7,20:14,20-diepoxykaur-16-en-15-one |
| Rubescensin B |
| (1S,4S,6S,8R,9R,12S,13S,16R)-6,9-Dihydroxy-7,7-dimethyl-17-methylene-3,10-dioxapentacyclo[14.2.1.0.0.0]nonadecane-2,18-dione |
| 5H-5a,8-Methano-11H-cyclohepta[c]furo[3,4-e][1]benzopyran-5,6(7H)-dione, decahydro-2,13-dihydroxy-1,1-dimethyl-7-methylene-, (2S,3aS,5aS,8R,10aS,10bS,13R,13aR)- |
| 5H-5a,8-Methano-11H-cyclohepta(c)furo(3,4-e)(1)benzopyran-5,6(7H)-dione, decahydro-2,13-dihydroxy-1,1-dimethyl-7-methylene-, (2S,3as,5as,7R,8R,10aS,10bS,13R,13aR)- |
