Introduction：Basic information about CAS 29550-13-8|Negletein, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Negletein |
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| CAS Number | 29550-13-8 | Molecular Weight | 284.26300 |
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| Density | 1.42g/cm3 | Boiling Point | 541.1ºC at 760mmHg |
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| Molecular Formula | C16H12O5 | Melting Point | 218-220ºC |
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| MSDS | / | Flash Point | 207.5ºC |
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Names
| Name | 5,6-dihydroxy-7-methoxyflavone |
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| Synonym | More Synonyms |
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Negletein BiologicalActivity
| Description | Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 and 10.8 μM, respectively[1]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Interleukin RelatedResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
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| References | [1]. Phan CW, et al. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Biofactors. 2016 Nov 12;42(6):591-599. [2]. Singh B, et al. Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth.Nat Prod Res. 2013;27(23):2227-30. |
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Chemical & Physical Properties
| Density | 1.42g/cm3 |
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| Boiling Point | 541.1ºC at 760mmHg |
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| Melting Point | 218-220ºC |
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| Molecular Formula | C16H12O5 |
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| Molecular Weight | 284.26300 |
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| Flash Point | 207.5ºC |
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| Exact Mass | 284.06800 |
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| PSA | 79.90000 |
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| LogP | 2.87980 |
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| Vapour Pressure | 2.54E-12mmHg at 25°C |
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| Index of Refraction | 1.668 |
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| InChIKey | ZTHLHHDJRXJGRX-UHFFFAOYSA-N |
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| SMILES | COc1cc2oc(-c3ccccc3)cc(=O)c2c(O)c1O |
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| Storage condition | 2-8℃ |
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Safety Information
| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36 |
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| HS Code | 2914509090 |
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Customs
| HS Code | 2914509090 |
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| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| BAICALEIN-7-METHYL ETHER |
| 7-O-Methylbaicalein |
| 5,6-dihydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one |
| 5,6-dihydroxy-7-methoxy-2-phenyl-4H-chromen-4-one |
| BAICALEIN METHYL ETHER |
| NEGLETEIN |
| 5,6-dihydroxy-7-methoxy-2-phenyl-chromen-4-one |
