CAS 5289-74-7|Hydroxyecdysone
Introduction：Basic information about CAS 5289-74-7|Hydroxyecdysone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Hydroxyecdysone | ||
|---|---|---|---|
| CAS Number | 5289-74-7 | Molecular Weight | 480.634 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 702.1±60.0 °C at 760 mmHg |
| Molecular Formula | C27H44O7 | Melting Point | 242-244 °C |
| MSDS | ChineseUSA | Flash Point | 392.4±29.4 °C |
Names
| Name | 20-hydroxyecdysone |
|---|---|
| Synonym | More Synonyms |
Hydroxyecdysone BiologicalActivity
| Description | Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Cyanotis arachnoides C.B.Clarke which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1].Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Apoptosis >>CaspaseSignaling Pathways >>Autophagy >>Autophagy |
| References | [1]. Liu H, et al. E93 predominantly transduces 20-hydroxyecdysone signaling to induce autophagy and caspase activity in Drosophila fat body. Insect Biochem Mol Biol. 2014 Feb;45:30-9. [2]. Phungphong S, et al. 20-Hydroxyecdysone attenuates cardiac remodeling in spontaneously hypertensive rats. Steroids. 2017 Oct;126:79-84. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 702.1±60.0 °C at 760 mmHg |
| Melting Point | 242-244 °C |
| Molecular Formula | C27H44O7 |
| Molecular Weight | 480.634 |
| Flash Point | 392.4±29.4 °C |
| Exact Mass | 480.308716 |
| PSA | 138.45000 |
| LogP | -0.53 |
| Vapour Pressure | 0.0±5.0 mmHg at 25°C |
| Index of Refraction | 1.597 |
| InChIKey | NKDFYOWSKOHCCO-YPVLXUMRSA-N |
| SMILES | CC(C)(O)CCC(O)C(C)(O)C1CCC2(O)C3=CC(=O)C4CC(O)C(O)CC4(C)C3CCC12C |
| Storage condition | 2-8°C |
| Water Solubility | alcohol: soluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >9 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 350 ug/kg
- SEX/DURATION :
- male 7 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA - TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 100 nmol/L
- REFERENCE :
- ENZYAS Enzymologia. (The Hague, Netherlands) V.1-43, 1936-72. Volume(issue)/page/year: 41,183,1971
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 100 nmol/L
- REFERENCE :
- ENZYAS Enzymologia. (The Hague, Netherlands) V.1-43, 1936-72. Volume(issue)/page/year: 41,183,1971
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | FZ8060000 |
| Packaging Group | II; III |
| Hazard Class | 4.1 |
| HS Code | 2937290090 |
Customs
| HS Code | 2937290090 |
|---|
Articles63
More Articles| Functions of nuclear receptor HR3 during larval-pupal molting in Leptinotarsa decemlineata (Say) revealed by in vivo RNA interference. Insect Biochem. Mol. Biol. 63 , 23-33, (2015) Our previous results revealed that RNA interference-aided knockdown of Leptinotarsa decemlineata FTZ-F1 (LdFTZ-F1) reduced 20E titer, and impaired pupation. In this study, we characterized a putative ... | |
| Identification of two juvenile hormone inducible transcription factors from the silkworm, Bombyx mori. J. Insect Physiol. 80 , 31-41, (2015) Juvenile hormone (JH) regulates many physiological processes in insects. However, the signal cascades in which JH is active have not yet been fully elucidated, particularly in comparison to another ma... | |
| A view through a chromatin loop: insights into the ecdysone activation of early genes in Drosophila. Nucleic Acids Res. 42(16) , 10409-24, (2014) The early genes are a key group of ecdysone targets that function at the top of the signaling hierarchy. In the presence of ecdysone, early genes exhibit a highly characteristic rapid and powerful ind... |
Synonyms
| CRUSTECDYSONE |
| 20-hydroxyecdysone |
| MFCD00036740 |
| (2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-Trihydroxy-10,13-dimethyl-17-[(2R,3R)-2,3,6-trihydroxy-6-methyl-2-heptanyl]-1,2,3,4,5,9,10,11,12,13,14,15,16,17-tetradecahydro-6H-cyclopenta[a]phenanthren-6-on |
| β-ecdysone |
| (2β,3β,5β,22R)-2,3,14,20,22,25-Hexahydroxycholest-7-en-6-one |
| Cholest-7-en-6-one, 2,3,14,20,22,25-hexahydroxy-, (2β,3β,5β,22R)- |
| Hydroxyecdysone |
| b-Ecdysone |
| Isoinokosterone |
| Commisterone |
| (2b,3b,5b,22R)-2,3,14,20,22,25-Hexahydroxycholest-7-en-6-one |
| Ecdysterone |
| (2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-Trihydroxy-10,13-dimethyl-17-[(2R,3R)-2,3,6-trihydroxy-6-methyl-2-heptanyl]-1,2,3,4,5,9,10,11,12,13,14,15,16,17-tetradecahydro-6H-cyclopenta[a]phenanthren-6-one |
