CAS 524-12-9|wedelolactone
| Common Name | wedelolactone | ||
|---|---|---|---|
| CAS Number | 524-12-9 | Molecular Weight | 314.246 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 498.4±45.0 °C at 760 mmHg |
| Molecular Formula | C16H10O7 | Melting Point | 315 °C |
| MSDS | ChineseUSA | Flash Point | 255.2±28.7 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | wedelolactone |
|---|---|
| Synonym | More Synonyms |
wedelolactone BiologicalActivity
| Description | Wedelolactone, a natural product from Ecliptae herba, suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex[1]. Wedelolactone inhibits 5-lipoxygenase (5-Lox) (IC50~2.5 μM) activity by an oxygen radical scavenging mechanism. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt[2]. Anti-cancer, anti-inflammatory, and antioxidant activities[3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Apoptosis >>CaspaseResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Metabolic Enzyme/Protease >>5-Lipoxygenase |
| Target | Caspase-11 5-lipoxygenase:2.5 μM (IC50) Apoptosis |
| References | [1]. Kobori M, et al. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. Cell Death Differ. 2004 Jan;11(1):123-30. [2]. Sarveswaran S, et al. Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Int J Oncol. 2012 Dec;41(6):2191-9. [3]. Liu YQ, et al. Wedelolactone enhances osteoblastogenesis by regulating Wnt/β-catenin signaling pathway but suppresses osteoclastogenesis by NF-κB/c-fos/NFATc1 pathway. Sci Rep. 2016 Aug 25;6:32260. |
Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 498.4±45.0 °C at 760 mmHg |
| Melting Point | 315 °C |
| Molecular Formula | C16H10O7 |
| Molecular Weight | 314.246 |
| Flash Point | 255.2±28.7 °C |
| Exact Mass | 314.042664 |
| PSA | 113.27000 |
| LogP | 2.75 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.759 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: 14 mg/mL, soluble |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H317 |
| Precautionary Statements | P280-P301 + P312 + P330 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22;R43 |
| Safety Phrases | 36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2932999099 |
Customs
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles27
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| Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice. Eur. J. Med. Chem. 56 , 361-7, (2012) The anticancer properties of demethylwedelolactone (DWEL) and wedelolactone (WEL), which are naturally occurring coumestans, have not been well characterized. In this study, we investigated the anti-i... |
Synonyms
| 6H-Benzofuro[3,2-c][1]benzopyran-6-one, 1,8,9-trihydroxy-3-methoxy- |
| wedelolactone |
| 1,8,9-Trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one |
| 6H-Benzofuro(3,2-c)(1)benzopyran-6-one, 1,8,9-trihydroxy-3-methoxy- |
| 1,8,9-trihydroxy-3-methoxycoumestan |
