CAS 596-85-0|Manool

Introduction：Basic information about CAS 596-85-0|Manool, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Manool BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Manool
CAS Number	596-85-0	Molecular Weight	290.48300
Density	0.93g/cm3	Boiling Point	368.2ºC at 760mmHg
Molecular Formula	C₂₀H₃₄O	Melting Point	49-52ºC(lit.)
MSDS	/	Flash Point	118.2ºC

Names

Name	manool
Synonym	More Synonyms

Manool BiologicalActivity

Description	Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle[1][2].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Others >>Others
In Vitro	Manool exhibits higher cytotoxic activity against HeLa (IC50=6.7 µg/mL) and U343 (IC50=6.7 µg/mL) cells[1]. Manool exhibits a protective effect against chromosome damage induced by MMS in HepG2 cells[3].
References	[1]. de Oliveira PF, et al. Manool, a Salvia officinalis diterpene, induces selective cytotoxicity in cancer cells. Cytotechnology. 2016;68(5):2139-2143. [2]. Pratsinis H, et al. Antiproliferative activity of Greek propolis. J Med Food. 2010;13(2):286-290. [3]. Nicolella HD, et al. Differential effect of manool--a diterpene from Salvia officinalis, on genotoxicity induced by methyl methanesulfonate in V79 and HepG2 cells. Food Chem Toxicol. 2014;72:8-12.

Chemical & Physical Properties

Density	0.93g/cm3
Boiling Point	368.2ºC at 760mmHg
Melting Point	49-52ºC(lit.)
Molecular Formula	C₂₀H₃₄O
Molecular Weight	290.48300
Flash Point	118.2ºC
Exact Mass	290.26100
PSA	20.23000
LogP	5.50240
Index of Refraction	1.5
InChIKey	CECREIRZLPLYDM-ZYKFHVCXSA-N
SMILES	C=CC(C)(O)CCC1C(=C)CCC2C(C)(C)CCCC12C

Safety Information

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
WGK Germany	3

Synonyms

8,14-labdadien-13-ol

MFCD01310996

MANOOL

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