Introduction：Basic information about CAS 728-61-0|Linderalactone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Linderalactone |
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| CAS Number | 728-61-0 | Molecular Weight | 244.286 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 437.9±45.0 °C at 760 mmHg |
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| Molecular Formula | C15H16O3 | Melting Point | / |
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| MSDS | / | Flash Point | 218.6±28.7 °C |
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Names
| Name | (R,E)-3,11-Dimethyl-8,9-dihydro-4H-4,7-(metheno)furo[3,2-c][1]oxacycloundecin-6(12H)-one |
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| Synonym | More Synonyms |
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Linderalactone BiologicalActivity
| Description | Linderalactone is an important sesquiterpene lactone isolated from Radix linderae. Linderalactone inhibits cancer growth by modulating the expression of apoptosis-related proteins and inhibition of JAK/STAT signalling pathway. Linderalactone also inhibits the proliferation of the lung cancer A-549 cells with an IC50 of 15 µM[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
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| In Vitro | Linderalactone (0-100 μM; 24 hours; A549 cells) treatment inhibits the growth of A549 cells concentration-dependently. The IC50 of linderalactone is 15 µM[1]. Linderalactone (7.5-30 μM; A549 cells) treatment induces apoptosis in A549 cells in a dose-dependent manner[1]. Linderalactone (7.5-30 μM; 24 hours; A549 cells) treatment induces G2/M cell cycle arrest of A549 cells dose-dependently[1]. Linderalactone (7.5-30 μM; A549 cells) inhibits the expression of STAT1, JAK1 and JAK2. Linderalactone could also inhibit the phosphorylation of pSTAT1, pSTAT-2, pJAK1 and pJAk2[1]. Cell Viability Assay[1] Cell Line: Lung cancer A549 cells Concentration: 0 μM, 1.6 μM, 3.2 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM Incubation Time: 24 hours Result: Inhibited the growth of A549 cells concentration-dependently. Apoptosis Analysis[1] Cell Line: Lung cancer A549 cells Concentration: 7.5 μM, 15 μM, 30 μM Incubation Time: Result: Induced apoptosis in A549 cells in a dose-dependent manner. Cell Cycle Analysis[1] Cell Line: Lung cancer A549 cells Concentration: 7.5 μM, 15 μM, 30 μM Incubation Time: 24 hours Result: Induced G2/M cell cycle arrest. Western Blot Analysis[1] Cell Line: Lung cancer A549 cells Concentration: 7.5 μM, 15 μM, 30 μM Incubation Time: Result: Inhibited the JAK/STAT pathway in A549 cells. |
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| References | [1]. Deng Y, et al. Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins, G2/M cell cycle arrest and inhibition of JAK/STAT signalling pathway. J BUON. 2019 Mar-Apr;24(2):566-571. [2]. Qinghua Sun, et al. Preparative Isolation and Purification of Linderalactone and Lindenenol from Radix linderae by HSCCC. Journal of Liquid Chromatography & Related Technologies. Aug 2005:113-121. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 437.9±45.0 °C at 760 mmHg |
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| Molecular Formula | C15H16O3 |
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| Molecular Weight | 244.286 |
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| Flash Point | 218.6±28.7 °C |
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| Exact Mass | 244.109940 |
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| PSA | 39.44000 |
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| LogP | 3.27 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.572 |
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| InChIKey | LWCKQMHMTSRRAA-UHFFFAOYSA-N |
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| SMILES | CC1=CCCC2=CC(OC2=O)c2c(C)coc2C1 |
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| Storage condition | 2-8C |
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Synonyms
| (1R)-3,8-Dimethyl-5,14-dioxatricyclo[10.2.1.0]pentadeca-2(6),3,8,12(15)-tetraen-13-one |
| 6H-4,7-Methenofuro[3,2-c]oxacycloundecin-6-one, 4,8,9,12-tetrahydro-3,11-dimethyl-, (4R)- |
| (R,10E)-4,8,9,12-Tetrahydro-3,11-dimethyl-6H-4,7-methenofuro[3,2-c]oxacycloundecin-6-one |
| 6H-4,7-Methenofuro(3,2-c)oxacycloundecin-6-one, 4,8,9,12-tetrahydro-3,11-dimethyl-, (4R,10E)- |
| Linderalactone |
