Introduction：Basic information about CAS 66176-93-0|cimicifugoside, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | cimicifugoside |
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| CAS Number | 66176-93-0 | Molecular Weight | 674.81800 |
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| Density | 1.38 g/cm3 | Boiling Point | / |
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| Molecular Formula | C37H54O11 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | cimicifugoside |
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| Synonym | More Synonyms |
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cimicifugoside BiologicalActivity
| Description | Cimicifugoside, a triterpenoid isolated from Cimicifuga simplex, is a novel specific nucleoside transport inhibitor that displays synergistic potentiation of methotrexate cytotoxicity[1]. Cimicifugoside shows immunosuppressive activity, which is preferentially directed toward B-cell function with larger doses being required for suppression of T-cell function[2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| Target | Nucleoside transport[1] |
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| References | [1]. Yawata A, et al. Inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity by cimicifugoside, a triterpenoid from Cimicifuga simplex. Eur J Pharm Sci. 2009 Nov 5;38(4):355-61. [2]. Hemmi H, et al. The immune response of splenic lymphocytes after cimicifugoside treatment in vitro and pretreatment in vivo. J Pharmacobiodyn. 1980 Dec;3(12):643-8. |
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Chemical & Physical Properties
| Density | 1.38 g/cm3 |
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| Molecular Formula | C37H54O11 |
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| Molecular Weight | 674.81800 |
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| Exact Mass | 674.36700 |
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| PSA | 156.67000 |
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| LogP | 2.94870 |
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| Index of Refraction | 1.619 |
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| InChIKey | XUJMHSCMPCZWOV-LAQQPNPASA-N |
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| SMILES | CC(=O)OC1CC23CC24CCC(OC2OCC(O)C(O)C2O)C(C)(C)C4CC=C3C2(C)CC3OC4(CC(C)C3C12C)OC(O)C1(C)OC41 |
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Synonyms
