CAS 2872-52-8|Disperse Red 1
Introduction：Basic information about CAS 2872-52-8|Disperse Red 1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Disperse Red 1 | ||
|---|---|---|---|
| CAS Number | 2872-52-8 | Molecular Weight | 314.33900 |
| Density | 1.23 g/cm3 | Boiling Point | 522.5ºC at 760 mmHg |
| Molecular Formula | C16H18N4O3 | Melting Point | 160-162 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 269.8ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Disperse Red 1 |
|---|---|
| Synonym | More Synonyms |
Disperse Red 1 BiologicalActivity
| Description | Disperse Red 1, an azobenzene derivative, is an azo textile dye extensively used for dyeing polyester fabrics in textile industry[1][2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | Exposure of human lymphocytes and a human hepatoma (HepG2) cell line to Disperse Red 1 in vitro at concentrations of 1.0 μg/mL and 2.0 μg/mL increases the frequency of micronuclei and also causes mutations in the Salmonella assay (13 revertants/μg)[2]. |
| In Vivo | To assess the toxic effects of Disperse Red 1 (DR1), on reproduction, sexually mature male mice (Mus musculus, strain CF-1) are orally (gavage) treated with single doses of the compound (20-500 mg/kg). Disperse Red 1 treatment causes testicular toxicity, increases frequency of sperm with abnormal morphology and decreases fertility. An increased amount of DNA damage is also detected in testis cells 16.6 and 24.9 days after treatments with 100 and 500 mg/kg[2]. |
| References | [1]. Laís da Silva Leite, et al. Monitoring Ecotoxicity of Disperse Red 1 Dye During photo-Fenton Degradation. Chemosphere. 2016 Apr;148:511-7. [2]. Fábio Henrique Fernandes, et al. Disperse Red 1 (Textile Dye) Induces Cytotoxic and Genotoxic Effects in Mouse Germ Cells. Reprod Toxicol. 2015 Jun;53:75-81. |
Chemical & Physical Properties
| Density | 1.23 g/cm3 |
|---|---|
| Boiling Point | 522.5ºC at 760 mmHg |
| Melting Point | 160-162 °C(lit.) |
| Molecular Formula | C16H18N4O3 |
| Molecular Weight | 314.33900 |
| Flash Point | 269.8ºC |
| Exact Mass | 314.13800 |
| PSA | 94.01000 |
| LogP | 4.35200 |
| Vapour Pressure | 9.57E-12mmHg at 25°C |
| Index of Refraction | 1.602 |
| InChIKey | FOQABOMYTOFLPZ-UHFFFAOYSA-N |
| SMILES | CCN(CCO)c1ccc(N=Nc2ccc([N+](=O)[O-])cc2)cc1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7470 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 30(1),50,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15 gm/kg/30D-I
- TOXIC EFFECTS :
- Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 30(1),50,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2095 No. of Facilities: 479 (estimated) No. of Industries: 8 No. of Occupations: 11 No. of Employees: 6237 (estimated) No. of Female Employees: 279 (estimated)
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H317 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R43 |
| Safety Phrases | S36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | KL0320000 |
| HS Code | 3204110000 |
Customs
| HS Code | 2927000090 |
|---|---|
| Summary | 2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
Articles18
More Articles| Assessment of the sensitizing potential of textile disperse dyes and some of their metabolites by the loose-fit coculture-based sensitization assay (LCSA). Arch. Toxicol. 86(5) , 733-40, (2012) Certain textile disperse dyes are known to cause allergic reactions of the human skin. Here, we examined 8 disperse dyes and 7 products of azo-cleavage of these dyes in an in vitro assay. We used the ... | |
| Chlorination treatment of aqueous samples reduces, but does not eliminate, the mutagenic effect of the azo dyes Disperse Red 1, Disperse Red 13 and Disperse Orange 1 Mutat. Res. 703(2) , 200-8, (2010) The treatment of textile effluents by the conventional method based on activated sludge followed by a chlorination step is not usually an effective method to remove azo dyes, and can generate products... | |
| Hepatotoxicity assessment of the azo dyes disperse orange 1 (DO1), disperse red 1 (DR1) and disperse red 13 (DR13) in HEPG2 cells. J. Toxicol. Environ. Health A 75(16-17) , 991-9, (2012) During the dyeing process in baths approximately 10 to 15% of the dyes used are lost and reach industrial effluents, thus polluting the environment. Studies showed that some classes of dyes, mainly az... |
Synonyms
| Amacel Scarlet GB |
| Acetate Fast Scarlet B |
| Dispersol Fast Scarlet B |
| Acetoquinone Light Scarlet BLZ |
| 2-[N-ethyl-4-[(4-nitrophenyl)diazenyl]anilino]ethanol |
| 4-[Ethyl(2-hydroxyethyl)amino]-4'-nitroazobenzene |
| EINECS 220-704-3 |
| Dispersive Ruby Zh |
| Disperse Scarlet Zh |
| N-Ethyl-N-(2-hydroxyethyl)-4-(4-nitrophenylazo)aniline |
| Disperse Red Zh |
| Disperse Scarlet B |
| Acetamine Scarlet B |
| MFCD00007312 |
