Introduction：Basic information about CAS 145158-71-0|Tegaserod, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tegaserod |
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| CAS Number | 145158-71-0 | Molecular Weight | 301.387 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 470.6±48.0 °C at 760 mmHg |
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| Molecular Formula | C16H23N5O | Melting Point | 180-183ºC |
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| MSDS | / | Flash Point | 238.4±29.6 °C |
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Names
| Name | tegaserod |
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| Synonym | More Synonyms |
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Tegaserod BiologicalActivity
| Description | Tegaserod is a serotonin receptor 4 agonist (HTR4) used in the treatment of irritable bowel syndrome (IBS). Anti-tumor activity[1]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Metabolic DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
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| Target | 5-HT4 Receptor |
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| In Vitro | Tegaserod (1.5 and 3 μM) induces apoptosis in the B16F10 murine melanoma cell line as well as several human melanoma cell lines[1]. Cell Viability Assay[1] Cell Line: B16F10 cells Concentration: 78 nM-10 μM Incubation Time: 72 hours Result: Had anti-cancer activity with IC50 values in the low micromolar range as assessed by MTT assay following 72 h of exposure. |
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| In Vivo | Tegaserod (5 mg/kg) delays tumor growth, reduces metastases, increases survival and suppresses p-S6 in vivo[1]. Animal Model: C57BL/6 J mice were subcutaneously injected with B16F10 cells[1] Dosage: 5 mg/kg Administration: Administered intraperitoneally (i.p.) daily for five consecutive days Result: Treatment significantly decreased tumor growth and resulted in only slight decreases in weight following treatment. |
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| References | [1]. Wei Liu, et al. Repurposing the serotonin agonist Tegaserod as an anticancer agent in melanoma: molecular mechanisms and clinical implications. J Exp Clin Cancer Res. 2020 Feb 21;39(1):38. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 470.6±48.0 °C at 760 mmHg |
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| Melting Point | 180-183ºC |
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| Molecular Formula | C16H23N5O |
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| Molecular Weight | 301.387 |
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| Flash Point | 238.4±29.6 °C |
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| Exact Mass | 301.190247 |
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| PSA | 159.89000 |
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| LogP | 2.91 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.597 |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R20/21/22 |
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| Safety Phrases | S36/37 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| (2E)-2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide |
| Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (2E)- |
| tegaserodum |
| (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N-pentylhydrazinecarboximidamide |
| Zelmac |
| MFCD06660144 |
| Tegaserode |
| (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N'-pentylhydrazinecarboximidamide |
| Tegaserod |
