CAS 99011-02-6|imiquimod

Introduction：Basic information about CAS 99011-02-6|imiquimod, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. imiquimod BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles144
7. Synonyms

Common Name	imiquimod
CAS Number	99011-02-6	Molecular Weight	240.304
Density	1.3±0.1 g/cm3	Boiling Point	456.7±48.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₆N₄	Melting Point	292-294°C
MSDS	ChineseUSA	Flash Point	230.0±29.6 °C
Symbol	GHS06	Signal Word	Danger

Names

Name	imiquimod
Synonym	More Synonyms

imiquimod BiologicalActivity

Description	Imiquimod is an immune response modifier and a toll-like receptor 7 agonist.
Related Catalog	Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Immunology/Inflammation >>Toll-like Receptor (TLR)Research Areas >>Inflammation/Immunology
Target	toll-like receptor 7[1]
In Vivo	In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secretecytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α[1].
References	[1]. Bilu D, et al. Imiquimod: modes of action. Br J Dermatol. 2003 Nov;149 Suppl 66:5-8.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	456.7±48.0 °C at 760 mmHg
Melting Point	292-294°C
Molecular Formula	C₁₄H₁₆N₄
Molecular Weight	240.304
Flash Point	230.0±29.6 °C
Exact Mass	240.137497
PSA	56.73000
LogP	3.46
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.681
InChIKey	DOUYETYNHWVLEO-UHFFFAOYSA-N
SMILES	CC(C)Cn1cnc2c(N)nc3ccccc3c21
Storage condition	Store at +4°C
Stability	Incompatible with strong oxidizing agents.

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300-H315-H319-H335
Precautionary Statements	P261-P264-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;Xi: Irritant;
Risk Phrases	R25;R36/37/38
Safety Phrases	S26-S45
RIDADR	UN 2811 6.1/PG 3
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles144

Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes.

Int. Immunol. 27(2) , 83-94, (2015)

Toll-like receptor 7 (TLR7) and TLR9 sense microbial single-stranded RNA (ssRNA) and ssDNA in endolysosomes. Nucleic acid (NA)-sensing in endolysosomes is thought to be important for avoiding TLR7/9 r...

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.

Nat. Commun. 6 , 6119, (2015)

Toll-like receptor 7 (TLR7) senses microbial-derived RNA but can also potentially respond to self-derived RNA. To prevent autoimmune responses, TLR7 is thought to localize in endolysosomes. Contrary t...

Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection.

Arch. Virol. 160(3) , 777-86, (2015)

A novel avian influenza A(H7N9) virus has emerged to infect humans in eastern China since 2013. An effective vaccine is needed because of the high mortality despite antiviral treatment and intensive c...

Synonyms

imiquimod

ALDARA

MFCD00866946

Recommended......