CAS 81110-73-8|Racecadotril

Introduction：Basic information about CAS 81110-73-8|Racecadotril, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Racecadotril BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles27
7. Synonyms

Common Name	Racecadotril
CAS Number	81110-73-8	Molecular Weight	385.477
Density	1.2±0.1 g/cm3	Boiling Point	574.5±50.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₃NO₄S	Melting Point	89ºC
MSDS	ChineseUSA	Flash Point	301.2±30.1 °C
Symbol	GHS07, GHS09	Signal Word	Warning

Names

Name	Racecadotril
Synonym	More Synonyms

Racecadotril BiologicalActivity

Description	Racecadotril (acetorphan), a potent enkephalinase inhibitor (IC50= 4.5 uM), protects endogenous enkephalins from degradation. IC50 value: 4.5 uMTarget: EnkephalinaseRacecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 uM. Unlike other medications used to treat diarrhea, which reduce intestinal motility, Racecadotril has an antisecretory effect-it reduces the secretion of water and electrolytes into the intestine. A small randomized controlled trial found Racecadotril to significantly reduce the duration and volume of watery diarrhea in children when given as an adjunct to oral rehydration therapy.
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>NeprilysinResearch Areas >>Neurological Disease
References	[1]. Marion Eberlin, Tobias Mück, Martin C. Michel, et al. A Comprehensive Review of the Pharmacodynamics, Pharmacokinetics, and Clinical Effects of the Neutral Endopeptidase Inhibitor Racecadotril. Front Pharmacol. 2012; 3: 93. [2]. Wu HT, Chang CK, Cheng KC, et al. Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats. Horm Metab Res. 2010 Apr;42(4):261-7. [3]. Szajewska H, Ruszczyński M, Chmielewska A, Wieczorek J. Systematic review: racecadotril in the treatment of acute diarrhoea in children. Aliment Pharmacol Ther. 2007 Sep 15;26(6):807-13. [4]. Schwartz JC. Racecadotril: a new approach to the treatment of diarrhoea. Int J Antimicrob Agents. 2000 Feb;14(1):75-9. [5]. Racecadotril

Description

Racecadotril (acetorphan), a potent enkephalinase inhibitor (IC50= 4.5 uM), protects endogenous enkephalins from degradation. IC50 value: 4.5 uMTarget: EnkephalinaseRacecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 uM. Unlike other medications used to treat diarrhea, which reduce intestinal motility, Racecadotril has an antisecretory effect-it reduces the secretion of water and electrolytes into the intestine. A small randomized controlled trial found Racecadotril to significantly reduce the duration and volume of watery diarrhea in children when given as an adjunct to oral rehydration therapy.

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>NeprilysinResearch Areas >>Neurological Disease

References

[1]. Marion Eberlin, Tobias Mück, Martin C. Michel, et al. A Comprehensive Review of the Pharmacodynamics, Pharmacokinetics, and Clinical Effects of the Neutral Endopeptidase Inhibitor Racecadotril. Front Pharmacol. 2012; 3: 93.

[2]. Wu HT, Chang CK, Cheng KC, et al. Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats. Horm Metab Res. 2010 Apr;42(4):261-7.

[3]. Szajewska H, Ruszczyński M, Chmielewska A, Wieczorek J. Systematic review: racecadotril in the treatment of acute diarrhoea in children. Aliment Pharmacol Ther. 2007 Sep 15;26(6):807-13.

[4]. Schwartz JC. Racecadotril: a new approach to the treatment of diarrhoea. Int J Antimicrob Agents. 2000 Feb;14(1):75-9.

[5]. Racecadotril

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	574.5±50.0 °C at 760 mmHg
Melting Point	89ºC
Molecular Formula	C₂₁H₂₃NO₄S
Molecular Weight	385.477
Flash Point	301.2±30.1 °C
Exact Mass	385.134766
PSA	97.77000
LogP	3.44
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.579
InChIKey	ODUOJXZPIYUATO-UHFFFAOYSA-N
SMILES	CC(=O)SCC(Cc1ccccc1)C(=O)NCC(=O)OCc1ccccc1
Storage condition	Refrigerator

Safety Information

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H400
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xn,N
Risk Phrases	22-50/53
Safety Phrases	60-61
RIDADR	UN 3077 9 / PGIII
RTECS	MB7606872
HS Code	2930909090

Customs

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles27

A comparative study of racecadotril and single dose octreotide as an anti-secretory agent in acute infective diarrhoea.

J. Assoc. Physicians India 60 , 12-5, (2012)

To assess the efficacy of single dose of octreotide and compare it with another antisecretory agent racecadotril in the management of acute infective diarrhea.A randomized control study was done in th...

Racecadotril versus loperamide: antidiarrheal research revisited.

Dig. Dis. Sci. 48(2) , 239-50, (2003)

Racecadotril is an enkephalinase inhibitor, presented as a purely antisecretory agent with advantages over the opiate-receptor agonist loperamide in the treatment of diarrhea. A critical review of the...

Quantitative analysis of racecadotril metabolite in human plasma using a liquid chromatography/tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 852(1-2) , 101-7, (2007)

Orally administered racecadotril is rapidly hydrolyzed to the more potent enkephalinase inhibitor thiorphan in vivo. A sensitive and specific liquid chromatography/tandem mass spectrometry method was ...

Synonyms

Acetorphan

Tiorfan

Hidrasec

Tiorfix

Redotil

MFCD00865520

Benzyl N-[3-(acetylsulfanyl)-2-benzylpropanoyl]glycinate

Racecadotril

RACECADOTRIL: ACETORPHAN

RACECADORTRIL

Glycine, N-[3-(acetylthio)-1-oxo-2-(phenylmethyl)propyl]-, phenylmethyl ester

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