CAS 2809-21-4|Etidronic acid

[1]. http://www.truthinaging.com/ingredients/etidronic-acid

CHEMICAL IDENTIFICATION

RTECS NUMBER :

SZ8562100

CHEMICAL NAME :

Phosphonic acid, (1-hydroxyethylidene)di-

CAS REGISTRY NUMBER :

2809-21-4

BEILSTEIN REFERENCE NO. :

1789291

LAST UPDATED :

199710

DATA ITEMS CITED :

11

MOLECULAR FORMULA :

C2-H8-O7-P2

MOLECULAR WEIGHT :

206.04

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1800 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

ACIEAY Angewandte Chemie, International Edition in English. (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.1- 1962- Volume(issue)/page/year: 14,94,1975 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

40 mg/kg

SEX/DURATION :

female 7 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :

SIGAAE Shika Igaku. Odontology. (Osaka Shika Gakkai, 1-47 Kyobashi, Higashi-ku, Osaka 540, Japan) V.1- 1930- Volume(issue)/page/year: 50,879,1987

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

200 mg/kg

SEX/DURATION :

female 7 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)

REFERENCE :

JODUA2 Journal of Osaka Dental University. (Osaka Dental Univ., 1-47, Kyobashi Higashi-ku, Osaka 540, Japan) V.1- 1967- Volume(issue)/page/year: 20,91,1986

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

200 mg/kg

SEX/DURATION :

female 7 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :

JODUA2 Journal of Osaka Dental University. (Osaka Dental Univ., 1-47, Kyobashi Higashi-ku, Osaka 540, Japan) V.1- 1967- Volume(issue)/page/year: 19,87,1985

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

200 mg/kg

SEX/DURATION :

female 8 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :

SIGAAE Shika Igaku. Odontology. (Osaka Shika Gakkai, 1-47 Kyobashi, Higashi-ku, Osaka 540, Japan) V.1- 1930- Volume(issue)/page/year: 49,837,1986

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

200 mg/kg

SEX/DURATION :

female 13 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 26(1),16A,1982

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

1400 mg/kg

SEX/DURATION :

female 11-17 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :

SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 22,47,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0985 No. of Facilities: 404 (estimated) No. of Industries: 10 No. of Occupations: 7 No. of Employees: 6655 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0985 No. of Facilities: 3273 (estimated) No. of Industries: 73 No. of Occupations: 46 No. of Employees: 44885 (estimated) No. of Female Employees: 3814 (estimated)

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