Introduction：Basic information about CAS 946075-13-4|isavuconazonium sulfate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | isavuconazonium sulfate |
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| CAS Number | 946075-13-4 | Molecular Weight | 814.835 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C35H36F2N8O9S2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | isavuconazonium sulfate |
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| Synonym | More Synonyms |
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isavuconazonium sulfate BiologicalActivity
| Description | Isavuconazonium sulfate (BAL8557-002), the prodrug of the active triazole Isavuconazole, is an orally active antifungal agent. Isavuconazonium sulfate is used for invasive aspergillosis and mucormycosis[1][2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Fungal |
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| References | [1]. Schmitt-Hoffmann AH, et al. Tissue Distribution and Elimination of Isavuconazole following Single and Repeat Oral-Dose Administration of Isavuconazonium Sulfate to Rats. Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01292-17. [2]. Murrell D, et al. Isavuconazonium sulfate: a triazole prodrug for invasive fungal infections. Int J Pharm Pract. 2017 Feb;25(1):18-30. |
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Chemical & Physical Properties
| Molecular Formula | C35H36F2N8O9S2 |
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| Molecular Weight | 814.835 |
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| Exact Mass | 814.201477 |
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| PSA | 273.42000 |
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| LogP | 5.06088 |
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| InChIKey | LWXUIUUOMSMZKJ-KLFWAVJMSA-M |
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| SMILES | CNCC(=O)OCc1cccnc1N(C)C(=O)OC(C)[n+]1cnn(CC(O)(c2cc(F)ccc2F)C(C)c2nc(-c3ccc(C#N)cc3)cs2)c1.O=S(=O)([O-])O |
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| Storage condition | -20℃ |
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Synonyms
| Cresemba |
| Isavuconazonium sulfate |
| (2-{[(1-{1-[(2R,3R)-3-[4-(4-Cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-1H-1,2,4-triazol-4-ium-4-yl}ethoxy)carbonyl](methyl)amino}-3-pyridinyl)methyl N-methylglycinate hydrogen sulfate |
