CAS 2498-50-2|4-Aminobenzamidine dihydrochloride
| Common Name | 4-Aminobenzamidine dihydrochloride | ||
|---|---|---|---|
| CAS Number | 2498-50-2 | Molecular Weight | 208.088 |
| Density | 1.26g/cm3 | Boiling Point | 289.8ºC at 760 mmHg |
| Molecular Formula | C7H11Cl2N3 | Melting Point | >300 °C(lit.) |
| MSDS | USA | Flash Point | 129ºC |
Names
| Name | 4-aminobenzenecarboximidamide,dihydrochloride |
|---|---|
| Synonym | More Synonyms |
4-Aminobenzamidine dihydrochloride BiologicalActivity
| Description | 4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor, also acting as a relatively weak urokinase type plasminogen activator (uPA) inhibitor (Ki=82 μM). 4-Aminobenzamidine can inhibit growth of a human prostate tumor in SCID mice[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Ser/Thr ProteaseResearch Areas >>Cancer |
| Target | Trypsin[1] Ki: 82 μM (uPA)[1] |
| References | [1]. Nguyen AL, et al. The development and application of a new affinity partitioning system for enzyme isolation and purification. Enzyme Microb Technol. 1990 Sep;12(9):663-8. [2]. Billström A, et al. The urokinase inhibitor p-aminobenzamidine inhibits growth of a human prostate tumor in SCID mice. Int J Cancer. 1995 May 16;61(4):542-7. |
Chemical & Physical Properties
| Density | 1.26g/cm3 |
|---|---|
| Boiling Point | 289.8ºC at 760 mmHg |
| Melting Point | >300 °C(lit.) |
| Molecular Formula | C7H11Cl2N3 |
| Molecular Weight | 208.088 |
| Flash Point | 129ºC |
| Exact Mass | 207.033005 |
| PSA | 75.89000 |
| LogP | 3.53810 |
| Vapour Pressure | 0.00216mmHg at 25°C |
| InChIKey | GHEHNICLPWTXJC-UHFFFAOYSA-N |
| SMILES | Cl.Cl.N=C(N)c1ccc(N)cc1 |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 240 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - meningeal changes Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 20,1045,1979
Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | CV6126500 |
Articles7
More Articles| Comparative study on the inhibition of plasmin and delta-plasmin via benzamidine derivatives. Biochem. Biophys. Res. Commun. 457(3) , 358-62, (2015) The potent fibrinolytic enzyme, plasmin has numerous clinical applications for recannulizing vessels obstructed by thrombus. Despite its diminutive size, 91 kDa, success in the recombinant expression ... | |
| p-Aminobenzamidine as a fluorescent probe for the active site of serine proteases. J. Biol. Chem. 257 , 3014, (1982) p-Aminobenzamidine is weakly fluorescent in neutral aqueous buffer, with excitation and emission maxima at 293 and 376 nm, respectively. Binding to trypsin results in a blue shift of the emission peak... | |
| Comparative studies on the inhibition of trypsin, plasmin, and thrombin by derivatives of benzylamine and benzamidine. Eur. J. Biochem. 6 , 502, (1968) |
Synonyms
| 4-AMBA dihydrochloride |
| Benzenecarboximidamide, 4-amino-, hydrochloride (1:2) |
| 4-aminobenzimidamide dihydrochloride |
| 4-aminobenzimidine dihydrochloride |
| MFCD00013001 |
| 4-aminobenzoamidine dihydrochloride |
| P-AMINOBENZAMIDINE DIHCL |
| 4-AMINOBENZAMIDINE 2HCL |
| Benzenecarboximidamide,4-amino-,dihydrochloride |
| 4-Aminobenzenecarboximidamide dihydrochloride |
| p-Aminobenzamidine dihydrochloride |
| Benzamidine,p-amino-,dihydrochloride |
| EINECS 219-692-2 |
| 4-Aminobenzamidine Dihydrochloride |
