Introduction：Basic information about CAS 2295-31-0|2,4-Thiazolidinedione, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
2,4-Thiazolidinedione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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In Vitro
PPARγ 激动剂。胰岛素增敏剂。
Chemical & Physical Properties
Density
1.5±0.1 g/cm3
Boiling Point
178-179 ºC (19 mmHg)
Melting Point
123-126 ºC
Molecular Formula
C3H3NO2S
Molecular Weight
117.13
Flash Point
138.7±19.3 °C
Exact Mass
116.988449
PSA
71.47000
LogP
-0.54
Vapour Pressure
0.0±0.6 mmHg at 25°C
Index of Refraction
1.577
InChIKey
ZOBPZXTWZATXDG-UHFFFAOYSA-N
SMILES
O=C1CSC(=O)N1
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
XJ5775000
CHEMICAL NAME :
2,4-Thiazolidinedione
CAS REGISTRY NUMBER :
2295-31-0
BEILSTEIN REFERENCE NO. :
0110700
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C3-H3-N-O2-S
MOLECULAR WEIGHT :
117.13
WISWESSER LINE NOTATION :
T5SVMV EHJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
335 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 9,274,1954
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles53
More Articles
Cytotoxicity of thiazolidinedione-, oxazolidinedione- and pyrrolidinedione-ring containing compounds in HepG2 cells.
Toxicol. In Vitro 29 , 1887-96, (2015)
Liver damage occurred in some patients who took troglitazone (TGZ) for type II diabetes. The 2,4-thiazolidinedione (TZD) ring in TGZ's structure has been implicated in its hepatotoxicity. To further e...
Differential cardiovascular outcomes after dipeptidyl peptidase-4 inhibitor, sulfonylurea, and pioglitazone therapy, all in combination with metformin, for type 2 diabetes: a population-based cohort study.
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Data on the comparative effectiveness of oral antidiabetics on cardiovascular outcomes in a clinical practice setting are limited. This study sought to determine whether a differential risk of cardiov...
Effects of Various 5,7-Dihydroxyflavone Analogs on Adipogenesis in 3T3-L1 Cells.
Biol. Pharm. Bull. 38 , 1794-800, (2015)
We studied the effects of twelve 5,7-dihydroxyflavone analogs on adipogenesis in 3T3-L1 cells. Among the compounds, luteolin, diosmetin, and chrysoeriol partly inhibited adipogenesis by blocking the a...
